7,8-dihydro-1H,6H-(1,4)dioxepino(2,3-f)benzimidazole-2-thiol | 81864-58-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 7,8-dihydro-1H,6H-(1,4)dioxepino(2,3-f)benzimidazole-2-thiol
• 英文别名: 7,8-dihydro-1H,6H-[1,4]dioxepino[2,3-f]benzimidazole-2-thiol；3,6,7,8-tetrahydro-1H-[1,4]dioxepino[2,3-f]benzimidazole-2-thione
• CAS: 81864-58-6
• 化学式: C₁₀H₁₀N₂O₂S
• mdl: MFCD01105778
• 分子量: 222.268
• InChiKey: OFJYDOHABMNROX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7,8-dihydro-1H,6H-(1,4)dioxepino(2,3-f)benzimidazole-2-thiol 在 氢氧化钾 、 sodium hydroxide 作用下， 以 水 、 异丙醇 、 丙酮 为溶剂， 反应 130.0h， 生成 (2-Methylsulfanyl-7,8-dihydro-6H-5,9-dioxa-1,3-diaza-cyclohepta[f]inden-1-yl)-acetic acid methyl ester
  参考文献：
  名称：

  Synthesis and antiinflammatory activity of new derivatives of 5,6-dialkoxy-2-mercaptobenz-imidazolylacetic acids

  摘要：

  DOI：

  10.1007/bf02464165
• 作为产物：
  描述：

  3,4-dihydro-2H-1,5-benzodioxepine-7,8-diamine 生成 7,8-dihydro-1H,6H-(1,4)dioxepino(2,3-f)benzimidazole-2-thiol
  参考文献：
  名称：

  Imidazole derivatives

  摘要：

  Tricyclic imidazole derivatives of the formula ##STR1## wherein R.sup.1 is 2-pyridyl optionally substituted by lower alkyl or lower alkoxy, n is the integer 0 or 1, R.sup.2 is hydrogen or lower alkyl, R.sup.3 and R.sup.4, independently, are hydrogen or lower alkyl, A is a group of the formula ##STR2## m is the integer 2 or 3, R.sup.5, R.sup.6, R.sup.7 and R.sup.8, independently, are hydrogen or lower alkyl, and R.sup.9 is hydrogen and R.sup.10 is hydrogen or lower alkyl or R.sup.9 and R.sup.10 taken together are oxo, provided that at least one of R.sup.3 and R.sup.4 is lower alkyl when A is a group of the formula --CH.dbd.CH--CH.dbd.CH-- or --(CH.sub.2).sub.4 --, and their pharmaceutically acceptable acid addition salts. The compounds of formula I inhibit gastric acid secretion and prevent the formation of gastric ulcers.

  公开号：

  US04435406A1

文献信息

• COMPOUNDS, COMPOSITIONS COMPRSING SAME, AND METHODS RELATED THERETO
  申请人：UNIVERSITY OF IOWA RESEARCH FOUNDATION

  公开号：US20160115136A1

  公开（公告）日：2016-04-28

  Disclosed herein are compounds, such as benzimidazole derivatives, and composition, such as pharmaceutical compositions, and methods related thereto for treating or preventing microbial infections. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• US4435406A
  申请人：——

  公开号：US4435406A

  公开（公告）日：1984-03-06
• US4554280A
  申请人：——

  公开号：US4554280A

  公开（公告）日：1985-11-19
• US4599347A
  申请人：——

  公开号：US4599347A

  公开（公告）日：1986-07-08
• [EN] COMPOUNDS, COMPOSITIONS COMPRISING SAME, AND METHODS RELATED THERETO<br/>[FR] COMPOSÉS, COMPOSITIONS LES COMPRENANT ET PROCÉDÉS ASSOCIÉS
  申请人：UNIV IOWA RES FOUND

  公开号：WO2014160405A1

  公开（公告）日：2014-10-02

  Discloaed herein are compounds, such as benzimidazole derivatives, and composition, such as pharmaceutical compoistions, and methods related thereto for treating or preventing microbial infections. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.