3-(2-oxo-1-phenyl-3H-indol-3-yl)indol-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(2-oxo-1-phenyl-3H-indol-3-yl)indol-2-one
• 化学式: C₂₂H₁₄N₂O₂
• 分子量: 338.4
• InChiKey: KJODJWBGMWLEOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  49.7
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Screening Assays Using Stem Cells and Stem Cell-Derived Neurons from Mouse Models of Alzheimer's Disease
  申请人：The Trustees of Columbia University in the City of New York

  公开号：US20140171380A1

  公开（公告）日：2014-06-19

  Successful CNS drug discovery requires a scalable, highly physiological neuronal model. Using directed differentiation of mouse embryonic stem (mES) cells, including mES cells isolated from a mouse model of Alzheimer's disease (AD), a highly homogeneous primary neuronal model amenable to phenotypic assays for production and synaptotoxicity of amyloid β-peptide was developed. This model furnishes a highly physiological and AD-relevant platform suitable for high throughput small molecule and functional genetic screens, providing specific small molecule compounds identified by such screens.
• US9696306B2
  申请人：——

  公开号：US9696306B2

  公开（公告）日：2017-07-04