A facile synthesis of N,3-disubstituted indoles and 3-hydroxyl indolines via an intramolecular SNAr of fluorinated amino alcohols
作者:Cheng-yi Chen、Robert A. Reamer
DOI:10.1016/j.tetlet.2009.01.049
日期:2009.4
method for the preparation of N,3-disubstituted indoles and 3-hydroxyl indolines. This synthetic strategy relies on an epoxide-opening followed by an intramolecular SNAr of the resulting fluoroaryl amino alcohols. The reaction afforded 3-hydroxyl indolines when carried out at lower temperature for the derivatives bearing multi-fluorine substituents at the aromatic ring.