9-Hydroxy-6-methylnonanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 9-Hydroxy-6-methylnonanoic acid
• 英文别名: 9-hydroxy-6-methylnonanoic acid
• 化学式: C₁₀H₂₀O₃
• 分子量: 188.26
• InChiKey: KVWNTAPEFSVTQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Substituted pyridyl-cycloalkyl-carboxylic acids, compositions containing them and medical uses thereof
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US10172814B2

  公开（公告）日：2019-01-08

  The present invention relates to substituted Pyridyl-cycloalkyl-carboxylic acids of general formula (I), to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular in mammals, such as diseases associated with pains, or for the treatment or prophylaxis of pain syndromes (acute and chronic), inflammatory-induced pain, pelvic pain, cancer-associated pain, endometriosis-associated pain as well as endometriosis and adenomyosis as such, cancer as such, and proliferative diseases as such like endometriosis.

  本发明涉及通式（I）的取代吡啶基-环烷基-羧酸、包含上述化合物的药物组合物和组合物，以及使用上述化合物制造药物组合物，用于治疗或预防疾病，尤其是哺乳动物的疾病、如与疼痛相关的疾病，或用于治疗或预防疼痛综合征（急性和慢性）、炎症引起的疼痛、盆腔疼痛、癌症相关疼痛、子宫内膜异位症相关疼痛以及子宫内膜异位症和子宫腺肌症、癌症以及子宫内膜异位症等增殖性疾病。
• SUBSTITUTED PYRIDYL-CYCLOALKYL-CARBOXYLIC ACIDS, COMPOSITIONS CONTAINING THEM AND MEDICAL USES THEREOF
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20170354620A1

  公开（公告）日：2017-12-14

  The present invention relates to substituted Pyridyl-cycloalkyl-carboxylic acids of general formula (I), to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular in mammals, such as diseases associated with pains, or for the treatment or prophylaxis of pain syndromes (acute and chronic), inflammatory-induced pain, pelvic pain, cancer-associated pain, endometriosis-associated pain as well as endometriosis and adenomyosis as such, cancer as such, and proliferative diseases as such like endometriosis.
• [EN] PROCESS FOR THE EXTRACTION AND PURIFICATION OF LONG-CHAIN BI-FUNCTIONAL SUBERIN ACIDS FROM CORK<br/>[FR] PROCESSUS POUR L'EXTRACTION DU LIÈGE ET LA PURIFICATION D'ACIDES DE SUBÉRINE À DOUBLE FONCTION ET À LONGUE CHAÎNE
  申请人：INST SUPERIOR AGRONOMIA

  公开号：WO2014092591A1

  公开（公告）日：2014-06-19

  The present application describes a multi-step process for the isolation and purification of some of the main suberin acids from cork, based in solvent-fractionation and chromatographic techniques, affording these compounds in very-high purity, in excess of 99.5 %. Cork is first extracted with solvents and suberin is then depolymerised. The ensuing suberin acids mixtures are then partitioned using differential temperature and solvent-solubility precipitation. The fractions enriched in the different suberin acids thus obtained, are sequentially treated by medium-pressure normal phase chromatography (MPLC) and high-performance reversed-phase chromatography (HPLC), leading to individual suberin acid purities approaching 100 % purity. The process of the present invention is useful for several industrial applications to provide compounds which may be applied to pharmaceuticals, cosmetics, surfactants, engineering polymers, and bio-mimetic membranes.