6-Methylcyclohexa-1,4-diene-1-carboxamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 6-Methylcyclohexa-1,4-diene-1-carboxamide
• 英文别名: 6-methylcyclohexa-1,4-diene-1-carboxamide
• 化学式: C₈H₁₁NO
• 分子量: 137.18
• InChiKey: FUDBXNPJURCNPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Photoactivated chemical bleaching of dyes
  申请人：GE Healthcare Bio-Sciences Corp.

  公开号：US10175174B2

  公开（公告）日：2019-01-08

  Methods comprising the use of photoactivated chemical bleaching for detecting multiple targets in a biological sample are provided. The methods include the steps of providing a biological sample including multiple targets, binding at least one probe to one or more target present in the sample, and detecting a signal from the probe. The method further includes the steps of contacting the sample comprising the bound probe with an electron transfer reagent, as well as an optional additive which prevents target modification during photoactivated chemical bleaching, and irradiating the sample, thereby initiating a photoreaction that substantially inactivates the probe by photoactivated chemical bleaching. The method further includes the steps of binding at least one probe to one or more target present in the sample, and detecting a signal from the probe. The process of binding, defecting and bleaching may be iteratively repeated.

  本发明提供的方法包括使用光活化化学漂白来检测生物样本中的多个靶标。这些方法包括以下步骤：提供包括多个靶标的生物样本，将至少一个探针与样本中的一个或多个靶标结合，并检测探针发出的信号。该方法还包括以下步骤：将包含结合探针的样品与电子转移试剂以及可选的添加剂接触，该添加剂可防止在光活化化学漂白过程中靶标被修饰；照射样品，从而启动光反应，通过光活化化学漂白使探针基本失活。该方法还包括以下步骤：将至少一个探针与样品中存在的一个或多个靶标结合，以及检测来自探针的信号。结合、缺陷和漂白过程可反复进行。
• PHOTOACTIVATED CHEMICAL BLEACHING OF DYES
  申请人：Clarient Diagnostic Services, Inc.

  公开号：EP2932270A1

  公开（公告）日：2015-10-21
• [EN] PHOTOACTIVATED CHEMICAL BLEACHING OF DYES<br/>[FR] BLANCHIMENT CHIMIQUE PHOTOACTIVÉ DE COLORANTS
  申请人：CLARIENT DIAGNOSTIC SERVICES INC

  公开号：WO2014093455A1

  公开（公告）日：2014-06-19

  Methods comprising the use of photoactivated chemical bleaching for detecting multiple targets in a biological sample are provided. The methods include the steps of providing a biological sample including multiple targets, binding at least one probe to one or more target present in the sample, and detecting a signal from the probe. The method further includes the steps of contacting the sample comprising the bound probe with an electron transfer reagent, as well as an optional additive which prevents target modification during photoactivated chemical bleaching, and irradiating the sample, thereby initiating a photoreaction that substantially inactivates the probe by photoactivated chemical bleaching. The method further includes the steps of binding at least one probe to one or more target present in the sample, and detecting a signal from the probe. The process of binding, detecting and bleaching may be iteratively repeated.