3-[(4-fluorophenyl)methyl]-4-(2-methyl-1H-indol-3-yl)pyrrole-2,5-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-[(4-fluorophenyl)methyl]-4-(2-methyl-1H-indol-3-yl)pyrrole-2,5-dione
• 化学式: C₂₀H₁₅FN₂O₂
• 分子量: 334.3
• InChiKey: ITOFJPPWMWDIMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  62
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• USE OF MALEIMIDE DERIVATIVES FOR PREVENTING AND TREATING CANCER
  申请人：Centogene AG

  公开号：EP2928465A2

  公开（公告）日：2015-10-14
• [EN] USE OF MALEIMIDE DERIVATIVES FOR PREVENTING AND TREATING CANCER<br/>[FR] UTILISATION DE DÉRIVÉS DE MALÉIMIDE POUR LA PRÉVENTION ET LE TRAITEMENT DU CANCER
  申请人：CENTOGENE AG

  公开号：WO2014090396A2

  公开（公告）日：2014-06-19

  The present invention is related to a compound of formula (I) a pharmaceutically acceptable salt thereof, a hydrate thereof, a solvate thereof, a metabolite thereof or a prodrug thereof; for use in a method for the treatment and/or prevention of cancer, wherein X is selected from the group consisting of N-R1, O and S; R1 is selected from the group consisting of alkyl, cycloalkyl, aryl, arylalkyl and hydrogen; R2 is selected from the group consisting of indolyl, substituted indolyl, azaindolyl and substituted azaindolyl; and R3 is selected from the group consisting of aryl, substituted aryl, unsubstituted heteroaryl, heterocyclyl and substituted heterocyclyl.