dimethyl 1-[trimethylsiloxy(4-methoxyphenyl)methyl]cyclopropene-3,3-dicarboxylate | 1001206-16-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: dimethyl 1-[trimethylsiloxy(4-methoxyphenyl)methyl]cyclopropene-3,3-dicarboxylate
• 英文别名: Dimethyl 2-[(4-methoxyphenyl)-trimethylsilyloxymethyl]cycloprop-2-ene-1,1-dicarboxylate；dimethyl 2-[(4-methoxyphenyl)-trimethylsilyloxymethyl]cycloprop-2-ene-1,1-dicarboxylate
• CAS: 1001206-16-1
• 化学式: C₁₈H₂₄O₆Si
• 分子量: 364.47
• InChiKey: LKGTURALAZHHJD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.86
• 重原子数：
  25
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-甲氧基苯甲醛 、 dimethyl 1-(trimethylsilyl)cyclopropene-3,3-dicarboxylate 在 三(2,4,6-三甲氧基苯基)磷 作用下， 以 1,4-二氧六环 为溶剂， 以65%的产率得到dimethyl 1-[trimethylsiloxy(4-methoxyphenyl)methyl]cyclopropene-3,3-dicarboxylate
  参考文献：
  名称：

  Sila Morita−Baylis−Hillman Reaction of Cyclopropenes

  摘要：

  The first example of sila-Morita-Bayis-Hillman reaction between 1-silylcyclopropenes and carbonyl compounds has been demonstrated. This novel phosphine-catalyzed transformation features a 1,3-Brook rearrangement/elimination cascade and provides convenient access to a variety of 1-(silyloxymethyl)cyclopropenes, which are not easily available via traditional methods.

  DOI：

  10.1021/ja077437s

文献信息

• Sila Morita−Baylis−Hillman Reaction of Cyclopropenes
  作者：Stepan Chuprakov、Denis A. Malyshev、Alexander Trofimov、Vladimir Gevorgyan

  DOI：10.1021/ja077437s

  日期：2007.12.1

  The first example of sila-Morita-Bayis-Hillman reaction between 1-silylcyclopropenes and carbonyl compounds has been demonstrated. This novel phosphine-catalyzed transformation features a 1,3-Brook rearrangement/elimination cascade and provides convenient access to a variety of 1-(silyloxymethyl)cyclopropenes, which are not easily available via traditional methods.