(1'R,9'R)-17'-(cyclopropylmethyl)-4'-methylspiro[1,3-dioxolane-4,13'-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5,10-tetraene]

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: (1'R,9'R)-17'-(cyclopropylmethyl)-4'-methylspiro[1,3-dioxolane-4,13'-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5,10-tetraene]
• 化学式: C₂₃H₂₉NO₂
• 分子量: 351.5
• InChiKey: ILKSVXOVMLGNLP-CTDXOEGXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Nitrogen Containing Morphinan Derivatives and the Use Thereof
  申请人：Purdue Pharma L.P.

  公开号：US20140171461A1

  公开（公告）日：2014-06-19

  The application is directed to compounds of Formula I-A and pharmaceutically acceptable salts and solvates thereof, wherein R 1a -R 3a , R 4 , Y, and Z are defined as set forth in the specification. The invention is also directed to use of compounds of Formula I-A to treat disorders responsive to the modulation of one or more opioid receptors, or as synthetic intermediates. Certain compounds of the present invention are especially useful for treating pain.
• US8937084B2
  申请人：——

  公开号：US8937084B2

  公开（公告）日：2015-01-20