5-[(3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-pyrimidine-2,4-dione

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核苷和核苷酸类似物
• 英文名称: 5-[(3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-pyrimidine-2,4-dione
• 化学式: C₉H₁₂N₂O₆
• 分子量: 244.2
• InChiKey: PTJWIQPHWPFNBW-DDUDGIQNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  128
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• MODIFIED POLYNUCLEOTIDES ENCODING CD28 MOLECULE
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20140171485A1

  公开（公告）日：2014-06-19

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• MODIFIED POLYNUCLEOTIDES FOR THE TREATMENT OF OTIC DISEASES AND CONDITIONS
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20150050354A1

  公开（公告）日：2015-02-19

  The present invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides in the treatment, prevention and/or amelioration of otic diseases or conditions.