2,4-dichloro-6-(3-chloro-4-fluoro-phenyl)-pyrimidine | 878809-98-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2,4-dichloro-6-(3-chloro-4-fluoro-phenyl)-pyrimidine
• 英文别名: 2,4-dichloro-6-(3-chloro-4-fluorophenyl)pyrimidine
• CAS: 878809-98-4
• 化学式: C₁₀H₄Cl₃FN₂
• 分子量: 277.513
• InChiKey: AVRMOBPNWJLZJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,4-dichloro-6-(3-chloro-4-fluoro-phenyl)-pyrimidine 在 四(三苯基膦)钯 碳酸氢钠 作用下， 以 甲醇 、 甲苯 为溶剂， 反应 32.0h， 生成 4-(3-chloro-4-fluorophenyl)-2-pyridin-3-yl-6-[4-(3-trifluoromethylpyridin-2-yl)-piperazin-1-yl]-pyrimidine
  参考文献：
  名称：

  [EN] BIARYL PIPERAZINYL-PYRIDINE ANALOGUES
  [FR] ANALOGUES DE BIARYL PIPERAZINYL-PYRIDINE

  摘要：

  公开号：

  WO2005007648A3
• 作为产物：
  描述：

  2,4-二氯嘧啶 在 正丁基锂 、 sodium hydroxide 、 溶剂黄146 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 乙醚 为溶剂， 反应 1.75h， 生成 2,4-dichloro-6-(3-chloro-4-fluoro-phenyl)-pyrimidine
  参考文献：
  名称：

  [EN] BIARYL PIPERAZINYL-PYRIDINE ANALOGUES
  [FR] ANALOGUES DE BIARYL PIPERAZINYL-PYRIDINE

  摘要：

  公开号：

  WO2005007648A3

文献信息

• Substituted biaryl piperazinyl-pyridine analogues
  申请人：Blum A. Charles

  公开号：US20060122394A1

  公开（公告）日：2006-06-08

  Substituted biaryl piperazinyl-pyridine analogues are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptors activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

  提供了替代的双芳基哌嗪基吡啶类似物，其化学式为：其中变量如本文所述。这些化合物是配体，可用于调节体内或体外特定受体的活性，并且在治疗人类、家养伴侣动物和家畜动物中与病理性受体激活相关的疾病方面特别有用。提供了用于治疗此类疾病的制药组合物和方法，以及用于受体定位研究的配体使用方法。
• Biaryl piperazinyl-pyridine analogues
  申请人：Bakthavatchalam Rajagopal

  公开号：US20070027155A1

  公开（公告）日：2007-02-01

  Biaryl piperazinyl-pyridine analogues are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

  提供了公式为：其中变量如此处所述的Biaryl piperazinyl-pyridine类似物。这些化合物是配体，可用于调节体内或体外特定受体活性，并且在治疗与人类、家养伴侣动物和家畜动物的病理性受体激活相关的疾病方面特别有用。提供了用于治疗此类疾病的制药组合物和方法，以及用于受体定位研究的这些配体的方法。
• Heteroaryl Substituted Piperazinyl-Pyridine Analogues
  申请人：Blum Charles A.

  公开号：US20080124384A1

  公开（公告）日：2008-05-29

  Substituted biaryl piperazinyl-pyridine analogues are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

  本发明提供了取代双芳基哌嗪基吡啶类似物，其化学式如下：其中变量如本文所述。这些化合物是配体，可用于调节体内或体外特定受体的活性，并在治疗与人类、家畜伴侣动物和家畜动物中的病理性受体激活相关的疾病方面特别有用。还提供了用于治疗此类疾病的制药组合物和方法，以及用于受体定位研究的这种配体的方法。
• SUBSTITUTED BIARYL PIPERAZINYL-PYRIDINE ANALOGUES
  申请人：Blum Charles A.

  公开号：US20110003813A1

  公开（公告）日：2011-01-06

  Substituted biaryl piperazinyl-pyridine analogues are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

  提供了替代的联苯基哌嗪基吡啶类似物，其化学式为：其中变量如本文所述。此类化合物是配体，可用于体内或体外调节特定受体活性，并且在治疗与人类、驯养的伴侣动物和家畜动物的病理性受体激活相关的疾病方面特别有用。提供了用于治疗此类疾病的制药组合物和方法，以及用于受体定位研究的配体使用方法。
• [EN] SUBSTITUTED BIARYL PIPERAZINYL-PYRIDINE ANALOGUES<br/>[FR] ANALOGUES DE BIARYLE PIPÉRAZINYL-PYRIDINE SUBSTITUÉS
  申请人：NEUROGEN CORP

  公开号：WO2006026135A3

  公开（公告）日：2006-06-15