2-(2-propynylthio)benzyl alcohol | 143895-30-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-propynylthio)benzyl alcohol
• 英文别名: (2-prop-2-ynylsulfanylphenyl)methanol
• CAS: 143895-30-1
• 化学式: C₁₀H₁₀OS
• 分子量: 178.255
• InChiKey: KNJKZEVJAHQGED-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  45.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(2-propynylthio)benzyl alcohol 以 甲苯 为溶剂， 反应 4.5h， 生成 methyl (7aS,12aS)-6,8,9,10,11,12a-hexahydrothiochromeno[3,4-b]indolizine-7a-carboxylate
  参考文献：
  名称：

  An expedient synthesis of diversified pyrrolizines and indolizines

  摘要：

  A general and rapid synthesis of new families of pyrrolizines and indolizines in good overall yields via an intramolecular [3+2]cycloaddition reaction is described. Diversity of substitutions can be achieved by the appropriate choice of readily available starting materials. The experimental procedures are straightforward and are performed under neutral conditions. New syntheses are also described for the preparation of N-propargylic 2-amino-benzaldehydes and S-propargylic 2-thiobenzaldehydes. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.11.146
• 作为产物：
  描述：

  2-(prop-2-ynylthio)benzoic acid 在 sodium hydroxide 、 LiAlH4 作用下， 以 四氢呋喃 、 水 为溶剂， 生成 2-(2-propynylthio)benzyl alcohol
  参考文献：
  名称：

  N-hydroxy-N-(3-(2-substituted phenyl)prop-2-enyl)ureas and thioureas

  摘要：

  本发明涉及N-羟基-N-[3-(2-取代苯基)丙-2-烯基]脲和硫脲，含有这些化合物的制剂，以及使用这些化合物作为5-脂氧合酶抑制剂的方法。

  公开号：

  US05130485A1

文献信息

• N-Hydroxy (thio)ureas as 5-lipoxygenase inhibitors
  申请人：ELI LILLY AND COMPANY

  公开号：EP0510947A1

  公开（公告）日：1992-10-28

  This invention relates to N-hydroxy-N-[3-(2-substituted phenyl)prop-2-enyl]ureas and thioureas, formulations containing those compounds, and methods of using such compounds as 5-lipoxygenase inhibiting agents.

  本发明涉及 N-羟基-N-[3-(2-取代苯基)丙-2-烯基]脲类和硫脲类化合物、含有这些化合物的制剂以及将这些化合物用作 5-脂氧合酶抑制剂的方法。
• US5130485A
  申请人：——

  公开号：US5130485A

  公开（公告）日：1992-07-14
• N-hydroxy-N-(3-(2-substituted phenyl)prop-2-enyl)ureas and thioureas
  申请人：Eli Lilly and Company

  公开号：US05130485A1

  公开（公告）日：1992-07-14

  This invention relates to N-hydroxy-N-[3-(2-substituted phenyl)prop-2-enyl]ureas and thioureas, formulations containing those compounds, and methods of using such compounds as 5-lipoxygenase inhibiting agents.

  本发明涉及N-羟基-N-[3-(2-取代苯基)丙-2-烯基]脲和硫脲，含有这些化合物的制剂，以及使用这些化合物作为5-脂氧合酶抑制剂的方法。
• An expedient synthesis of diversified pyrrolizines and indolizines
  作者：George Bashiardes、Imad Safir、Francis Barbot、Joelle Laduranty

  DOI：10.1016/j.tetlet.2003.11.146

  日期：2004.2

  A general and rapid synthesis of new families of pyrrolizines and indolizines in good overall yields via an intramolecular [3+2]cycloaddition reaction is described. Diversity of substitutions can be achieved by the appropriate choice of readily available starting materials. The experimental procedures are straightforward and are performed under neutral conditions. New syntheses are also described for the preparation of N-propargylic 2-amino-benzaldehydes and S-propargylic 2-thiobenzaldehydes. (C) 2003 Elsevier Ltd. All rights reserved.