1,2-Diiminoperylene-3-sulfonic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 1,2-Diiminoperylene-3-sulfonic acid
• 英文别名: 1,2-diiminoperylene-3-sulfonic acid
• 化学式: C₂₀H₁₂N₂O₃S
• 分子量: 360.4
• InChiKey: FNWPERZGQAFIBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  26
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  110
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Biological substance detection method
  申请人：Konica Minolta, Inc.

  公开号：EP2757378A2

  公开（公告）日：2014-07-23

  The present invention provides a biological substance detection method for specifically detecting a biological substance from a pathological specimen, by which method, when immunostaining using a fluorescent label and staining for morphological observation using a staining agent for morphological observation are simultaneously performed, the results of fluorescence observation and immunostaining can be assessed properly even if the fluorescent label and/or the staining agent is/are deteriorated by irradiation with an excitation light. The biological substance detection method according to the present invention is characterized in that the brightness retention rate of an immunostained part is in a range of 80% to 120% in relation to the brightness retention rate of a part stained for morphological observation when the fluorescent label used for the immunostaining is observed.

  本发明提供了一种从病理标本中特异性检测生物物质的生物物质检测方法，通过该方法，当使用荧光标签进行免疫染色和使用形态观察用染色剂进行形态观察染色同时进行时，即使荧光标签和/或染色剂因激发光照射而变质，也能正确评估荧光观察和免疫染色的结果。根据本发明的生物物质检测方法的特点是，在观察用于免疫染色的荧光标签时，免疫染色部分的亮度保持率与用于形态观察的染色部分的亮度保持率相比在 80% 至 120% 的范围内。
• METHOD FOR DETECTING BIOLOGICAL MATERIAL
  申请人：Konica Minolta, Inc.

  公开号：EP2833140A1

  公开（公告）日：2015-02-04

  The present invention provides a staining method in which the fluorescent staining properties in a fluorescently-immunostained specimen are not reduced even when an oil-based mounting medium is used. The present invention also provides a method of preventing deterioration of a fluorescent label caused by irradiation with excitation light and improving the light resistance in a fluorescently-immunostained specimen obtained by the staining method. The biological substance detection method according to the present invention is a biological substance detection method for specifically detecting a biological substance from a pathological specimen, which comprises the steps of: immunostaining the specimen with a fluorescent label; immobilizing the thus stained specimen; and mounting the thus immobilized specimen using a mounting medium comprising an organic solvent not freely miscible with water. In the biological substance detection method, the above-described mounting medium further comprises a discoloration inhibitor.

  本发明提供了一种染色方法，在这种方法中，即使使用油基装载介质，也不会降低荧光免疫染色标本的荧光染色特性。本发明还提供了一种方法，可防止荧光标签因激发光照射而变质，并提高通过染色方法获得的荧光免疫染色标本的耐光性。根据本发明的生物物质检测方法是一种从病理标本中特异性检测生物物质的生物物质检测方法，它包括以下步骤：用荧光标签对标本进行免疫染色；将这样染色的标本固定；以及使用由与水不能自由混溶的有机溶剂组成的装载介质装载这样固定的标本。在生物物质检测方法中，上述安装介质还包括变色抑制剂。
• PHOSPHOR AGGREGATE NANOPARTICLE USED IN FLUORESCENCE OBSERVATION
  申请人：Konica Minolta, Inc.

  公开号：EP3249403A1

  公开（公告）日：2017-11-29

  The present invention provides phosphor-integrated nanoparticles whose precipitation and/or aggregation, particularly aggregation can be inhibited upon carrying out immunostaining therewith and which can thus be used for staining even after long-term storage without requiring a complicated operation, the phosphor-integrated nanoparticles preferably maintaining excellent performance, such as staining properties, even after long-term storage. The phosphor-integrated nanoparticles of the present invention have an average sphericity (f) of 0.80 to 0.95 and preferably have an average circumference ratio (R) of 0.50 to 0.95. More preferably, the matrix of the particles contains an organic compound, the phosphor-integrated nanoparticles have an average particle size of 300 nm or less, and a biological component-binding molecule is bound on the particle surface.

  本发明提供的荧光粉整合纳米粒子在进行免疫染色时可抑制其沉淀和/或聚集，特别是聚集，因此即使在长期储存后也可用于染色，而无需进行复杂的操作，即使在长期储存后，荧光粉整合纳米粒子仍可保持良好的性能，如染色性能。本发明的荧光粉集成纳米粒子的平均球度（f）为 0.80 至 0.95，平均圆周率（R）最好为 0.50 至 0.95。更优选的是，颗粒的基质含有有机化合物，荧光粉整合纳米颗粒的平均粒径为 300 nm 或更小，颗粒表面结合有生物成分结合分子。
• Phosphor-integrated nanoparticles used in fluorescence observation
  申请人：Konica Minolta, Inc.

  公开号：US11391728B2

  公开（公告）日：2022-07-19

  The present invention may provide phosphor-integrated nanoparticles whose precipitation and/or aggregation, particularly aggregation can be inhibited upon carrying out immunostaining therewith and which can thus be used for staining even after long-term storage without requiring a complicated operation, the phosphor-integrated nanoparticles preferrably maintaining excellent performance, such as staining properties, even after long-term storage. The phosphor-integrated nanoparticles of the present invention have an average sphericity (f) of 0.80 to 0.95 and preferably have an average circumference ratio (R) of 0.50 to 0.95. More preferably, the matrix of the particles contains an organic compound, the phosphor-integrated nanoparticles have an average particle size of 300 nm or less, and a biological component-binding molecule is bound on the particle

  本发明可提供荧光粉整合纳米粒子，其沉淀和/或聚集，特别是聚集可在用其进行免疫染色时被抑制，因此即使在长期储存后也可用于染色，而无需复杂的操作，最好是荧光粉整合纳米粒子即使在长期储存后也能保持优异的性能，如染色性能。本发明的荧光粉集成纳米粒子的平均球度（f）为 0.80 至 0.95，平均周长比（R）最好为 0.50 至 0.95。更优选的是，颗粒的基质含有有机化合物，荧光粉整合纳米颗粒的平均粒径为 300 nm 或更小，颗粒上结合有生物成分结合分子。
• BIOLOGICAL SUBSTANCE DETECTION METHOD
  申请人：Konica Minolta, Inc.

  公开号：EP2755019B1

  公开（公告）日：2018-01-03