(12aS)-9-ethoxy-8-methyl-12a,13-dihydroindolo[2,1-c][1,4]benzodiazepin-6-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: (12aS)-9-ethoxy-8-methyl-12a,13-dihydroindolo[2,1-c][1,4]benzodiazepin-6-one
• 化学式: C₁₉H₁₈N₂O₂
• 分子量: 306.4
• InChiKey: ONXCANKKOJQNNQ-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  41.9
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• NOVEL BENZODIAZEPINE DERIVATIVES
  申请人：IMMUNOGEN, INC.

  公开号：US20180079823A1

  公开（公告）日：2018-03-22

  The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepines of formula (I) and (II), in which the diazepine ring (B) is fused with a heterocyclic ring (CD), wherein the heterocyclic ring is bicyclic or a compound of formula (III), in which the diazepine ring (B) is fused with a heterocyclic ring (C), wherein the heterocyclic ring is monocyclic. The invention provides cytotoxic dimers of these compounds. The invention also provides conjugates of the monomers and the dimers. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. The invention further relates to methods of using the compounds or conjugates for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
• US8765740B2
  申请人：——

  公开号：US8765740B2

  公开（公告）日：2014-07-01
• US8802667B2
  申请人：——

  公开号：US8802667B2

  公开（公告）日：2014-08-12