[(6S,8S,8aS)-6-dibutoxyphosphoryloxy-8-methyl-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-7-yl] benzoate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃二恶英
• 英文名称: [(6S,8S,8aS)-6-dibutoxyphosphoryloxy-8-methyl-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-7-yl] benzoate
• 化学式: C₂₉H₃₉O₉P
• 分子量: 562.6
• InChiKey: XXBPHOHNLHHDTA-XCERJNRVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  39
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  98.8
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• OLIGOSACCHARIDES AND OLIGOSACCHARIDE-PROTEIN CONJUGATES DERIVED FROM CLOSTRIDIUM DIFFICLE POLYSACCARIDE PS-I, METHODS OF SYNTHESIS AND USES THEREOF, IN PARTICULAR AS VACCINES AND DIAGNOSTIC TOOLS
  申请人：Seeberger Peter H.

  公开号：US20140193416A1

  公开（公告）日：2014-07-10

  The invention relates to a synthetic oligosaccharide representing part of the repeating unit of the Clostridium difficile glycopolymer PS-I and having the sequence of the pentasaccharide a-L-Rhap-(1→3)-β-D-Glcp-(1→4)-[a-L-Rhap-(1→3]-a-D-Glcp-(1→2)-a-D-Glcp or a synthetic fragment or derivative thereof. Preferably, the claimed synthetic oligosaccharide bears at least one linker L for conjugation to a carrier protein or for immobilization on a surface. Further aspects of the invention relate to advantageous methods for synthesizing said synthetic oligosaccharide and oligosaccharide-protein conjugate as well as to uses thereof, in particular as vaccines and diagnostic tools.

  本发明涉及一种合成寡糖，其代表Clostridium difficile糖聚合物PS-I重复单元的一部分，并具有五糖核苷酸序列a-L-Rhap-(1→3)-β-D-Glcp-(1→4)-[a-L-Rhap-(1→3]-a-D-Glcp-(1→2)-a-D-Glcp或其合成片段或衍生物。优选地，所述合成寡糖至少带有一种连接物L，用于与载体蛋白质结合或固定在表面上。本发明的其他方面涉及有利的方法，用于合成所述合成寡糖和寡糖-蛋白质结合物，以及其用途，特别是作为疫苗和诊断工具。
• ANTIBODIES FOR PREVENTION AND TREATMENT OF DISEASES CAUSED BY CLOSTRIDIUM DIFFICILE
  申请人：Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.

  公开号：US20160137724A1

  公开（公告）日：2016-05-19

  The present invention relates to an antibody having specificity for an immunogenic determinant consisting of the pentasaccharide repeating unit of the Clostridium difficile glycopolymer PS-I: α- L -Rhap-(1→3)-β- D -Glcp-(1→4)-[α- L -Rhap-(1→3)]-α- D -Glcp-(1→2)-α- D -Glcp or a fragment thereof. Said antibody is able to prevent and treat diseases caused by C. difficile . The present invention further pertains to a method of treating or preventing a disease caused by the pathogen Clostridium difficile , which comprises administering to a subject said antibody or a vaccine composition comprising said antibody.

  本发明涉及一种具有特异性的抗体，其针对克罗斯特菌困难梭菌糖聚合物PS-I的五糖重复单元或其片段的免疫表位。该抗体能够预防和治疗由C. difficile引起的疾病。本发明还涉及一种治疗或预防由病原体Clostridium difficile引起的疾病的方法，该方法包括向受试者注射所述抗体或包含所述抗体的疫苗组合物。
• US9238669B2
  申请人：——

  公开号：US9238669B2

  公开（公告）日：2016-01-19
• US9815889B2
  申请人：——

  公开号：US9815889B2

  公开（公告）日：2017-11-14