N-[(3S,6R)-6-acetyl-9-(carbamoylamino)-2-methyl-4-oxononan-3-yl]-3-[2-[2-[2-[2-(2,5-dioxopyrrolidin-1-yl)ethoxy]ethoxy]ethoxy]ethoxy]propanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[(3S,6R)-6-acetyl-9-(carbamoylamino)-2-methyl-4-oxononan-3-yl]-3-[2-[2-[2-[2-(2,5-dioxopyrrolidin-1-yl)ethoxy]ethoxy]ethoxy]ethoxy]propanamide
• 化学式: C₂₈H₄₈N₄O₁₀
• 分子量: 600.7
• InChiKey: DARCVULKGLPAOT-AMGIVPHBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  42
• 可旋转键数：
  25
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  193
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• HYDROPHILIC SELF-IMMOLATIVE LINKERS AND CONJUGATES THEREOF
  申请人：BioAlliance C.V.

  公开号：US20140193437A1

  公开（公告）日：2014-07-10

  The present disclosure provides compounds with a hydrophilic self-immolative linker, which is cleavable under appropriate conditions and incorporates a hydrophilic group to provide better solubility of the compound. The compounds of the present disclosure comprise a drug moiety, a targeting moiety capable of targeting a selected cell population, and a linker which contains an acyl unit, an optional spacer unit for providing distance between the drug moiety and the targeting moiety, a peptide linker which can be cleavable under appropriate conditions, a hydrophilic self-immolative linker, and an optional second self-immolative spacer or cyclization self-elimination linker.
• US9089614B2
  申请人：——

  公开号：US9089614B2

  公开（公告）日：2015-07-28
• US9408923B2
  申请人：——

  公开号：US9408923B2

  公开（公告）日：2016-08-09