methyl 2,3-difluoro-3-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)oxirane-2-carboxylate | 143582-66-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环氧化物
• 英文名称: methyl 2,3-difluoro-3-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)oxirane-2-carboxylate
• CAS: 143582-66-5
• 化学式: C₇H₃F₉O₃
• 分子量: 306.085
• InChiKey: DUNZOPISROVOSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.35
• 重原子数：
  19.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  38.83
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  1,2-bis-fluorosulfatoperfluoro-3-methylpentanois acid fluoride 在 cesium fluoride 作用下， 以 1,4-二氧六环 为溶剂， 反应 6.5h， 生成 methyl 2,3-difluoro-3-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)oxirane-2-carboxylate
  参考文献：
  名称：

  Interaction of perfluorinated α-fluorosulfatocarbonyl compounds with nucleophilic reagents

  摘要：

  alpha-Perfluorosulfatoperfluorocarbonyl compounds interact with alkaline metals halogenides to form the corresponding alpha-halo derivatives as a result of the direct nucleophilic substitution of the FSO3 group. Through the action of halogenide anions on perfluorinated alpha,beta-bis-fluorosulfatocarbonyl compounds, substitution by halogen of the FSO3 group in the alpha-position to the carbonyl takes place. However, the FSO3 group in the beta-position is cleaved, which allows alpha-substituted beta-dicarbonyl derivatives to be obtained.

  DOI：

  10.1016/s0022-1139(00)80858-1

文献信息

• Fluoroaliphatic esters of fluorosulfonic acid. 6. Interaction of fluorine-containing ?,?-bis-fluorosulfatocarbonyl compounds with nucleophilic reagents
  作者：V. M. Rogovik、N. I. Delyagina、A. F. A�rov、V. F. Cherstkov、S. R. Sterlin、L. S. German

  DOI：10.1007/bf00863085

  日期：1992.3

  Fluorine-containing alpha,beta-fluorosulfatocarbonyl compounds interact with halides of alkali metals with the formation of alpha-halogeno-beta-dicarbonyl derivatives.
• Perfluorinated α,β-unsaturated thyocyanats: synthesis, molecular rearrangements, intramolecular heterocyclizations
  作者：Vera Ya. Popkova

  DOI：10.1016/s0022-1139(00)83816-6

  日期：1991.9
• Interaction of perfluorinated α-fluorosulfatocarbonyl compounds with nucleophilic reagents
  作者：N.I. Delyagina、E.A. Avetisyan、V.M. Rogovik、V.F. Cherstkov、S.R. Sterlin、L.S. German

  DOI：10.1016/s0022-1139(00)80858-1

  日期：1993.12

  alpha-Perfluorosulfatoperfluorocarbonyl compounds interact with alkaline metals halogenides to form the corresponding alpha-halo derivatives as a result of the direct nucleophilic substitution of the FSO3 group. Through the action of halogenide anions on perfluorinated alpha,beta-bis-fluorosulfatocarbonyl compounds, substitution by halogen of the FSO3 group in the alpha-position to the carbonyl takes place. However, the FSO3 group in the beta-position is cleaved, which allows alpha-substituted beta-dicarbonyl derivatives to be obtained.