1-(6-methoxy-1H-indol-3-yl)-2,3-diphenyl-1,2-dihydroisoquinoline | 1207289-96-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-(6-methoxy-1H-indol-3-yl)-2,3-diphenyl-1,2-dihydroisoquinoline
• 英文别名: 1-(6-methoxy-1H-indol-3-yl)-2,3-diphenyl-1H-isoquinoline
• CAS: 1207289-96-0
• 化学式: C₃₀H₂₄N₂O
• 分子量: 428.533
• InChiKey: DGDNVRURHMQLLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  28.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  6-甲氧基吲哚 、 2-苯基乙炔基苯甲醛 、 苯胺 在 silver trifluoromethanesulfonate 、 sodium sulfate 作用下， 以 乙腈 为溶剂， 以90%的产率得到1-(6-methoxy-1H-indol-3-yl)-2,3-diphenyl-1,2-dihydroisoquinoline
  参考文献：
  名称：

  Synthesis of 1-(1H-Indol-3-yl)-1,2-dihydroisoquinolines via AgOTf-Catalyzed Three-Component Reactions of 2-Alkynylbenzaldehydes, Amines, and Indoles

  摘要：

  Three-component reactions of 2-alkynylbenzaldehydes, amines, and indoles catalyzed by AgOTf Under mild conditions afford the 1-(1H-indol-3-yl)-1,1-dihydroisoquinolines in good yields. This silver-catalyzed tandem reaction is found to be workable with various indoles. anilines or alkyl amines, and 2-alkynylbenzaldehydes with electron-withdrawing groups attached oil the aromatic backbone.

  DOI：

  10.1021/cc9001263

文献信息

• Synthesis of 1-(1<i>H</i>-Indol-3-yl)-1,2-dihydroisoquinolines via AgOTf-Catalyzed Three-Component Reactions of 2-Alkynylbenzaldehydes, Amines, and Indoles
  作者：Xingxin Yu、Jie Wu

  DOI：10.1021/cc9001263

  日期：2010.3.8

  Three-component reactions of 2-alkynylbenzaldehydes, amines, and indoles catalyzed by AgOTf Under mild conditions afford the 1-(1H-indol-3-yl)-1,1-dihydroisoquinolines in good yields. This silver-catalyzed tandem reaction is found to be workable with various indoles. anilines or alkyl amines, and 2-alkynylbenzaldehydes with electron-withdrawing groups attached oil the aromatic backbone.