5-[(4-Hydroxyphenyl)methylidene]-3-(2-methylphenyl)-2-(2-methylphenyl)imino-1,3-thiazolidin-4-one | 304894-29-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-[(4-Hydroxyphenyl)methylidene]-3-(2-methylphenyl)-2-(2-methylphenyl)imino-1,3-thiazolidin-4-one
• CAS: 304894-29-9
• 化学式: C₂₄H₂₀N₂O₂S
• mdl: MFCD01026746
• 分子量: 400.501
• InChiKey: BAJXYNPAUNXZHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  78.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-[(4-Hydroxyphenyl)methylidene]-3-(2-methylphenyl)-2-(2-methylphenyl)imino-1,3-thiazolidin-4-one 、 溴乙酸甲酯 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 4.0h， 生成 methyl 2-[4-[[3-(2-methylphenyl)-2-(2-methylphenyl)imino-4-oxo-1,3-thiazolidin-5-ylidene]methyl]phenoxy]acetate
  参考文献：
  名称：

  Design, synthesis, and antibiofilm activity of 2-arylimino-3-aryl-thiazolidine-4-ones

  摘要：

  A series of novel 2-arylimino-3-aryl-thiazolidine-4-ones was designed, synthesized and tested for in vitro antibiofilm activity against Staphylococcus epidermidis. Among them tested, some compounds with carboxylic acid groups showed good antibiofilm activity. The antibiofilm concentration of 1x was 6.25 mu M. The structure-activity relationships revealed that incorporation of 2-phenylfuran moiety could greatly enhance antibiofilm activity of thiazolidine-4-one. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.03.013
• 作为产物：
  描述：

  3-(2-甲基苯基)-2-(2-甲基苯基)亚氨基-1,3-噻唑烷-4-酮 、 对羟基苯甲醛 在 哌啶 作用下， 以 乙醇 为溶剂， 反应 3.0h， 生成 5-[(4-Hydroxyphenyl)methylidene]-3-(2-methylphenyl)-2-(2-methylphenyl)imino-1,3-thiazolidin-4-one
  参考文献：
  名称：

  Design, synthesis, and antibiofilm activity of 2-arylimino-3-aryl-thiazolidine-4-ones

  摘要：

  A series of novel 2-arylimino-3-aryl-thiazolidine-4-ones was designed, synthesized and tested for in vitro antibiofilm activity against Staphylococcus epidermidis. Among them tested, some compounds with carboxylic acid groups showed good antibiofilm activity. The antibiofilm concentration of 1x was 6.25 mu M. The structure-activity relationships revealed that incorporation of 2-phenylfuran moiety could greatly enhance antibiofilm activity of thiazolidine-4-one. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.03.013

文献信息

• Design, synthesis, and antibiofilm activity of 2-arylimino-3-aryl-thiazolidine-4-ones
  作者：Bin Pan、Ren-Zheng Huang、Shi-Qing Han、Di Qu、Ming-Li Zhu、Ping Wei、Han-Jie Ying

  DOI：10.1016/j.bmcl.2010.03.013

  日期：2010.4

  A series of novel 2-arylimino-3-aryl-thiazolidine-4-ones was designed, synthesized and tested for in vitro antibiofilm activity against Staphylococcus epidermidis. Among them tested, some compounds with carboxylic acid groups showed good antibiofilm activity. The antibiofilm concentration of 1x was 6.25 mu M. The structure-activity relationships revealed that incorporation of 2-phenylfuran moiety could greatly enhance antibiofilm activity of thiazolidine-4-one. (C) 2010 Elsevier Ltd. All rights reserved.