2-Pyridinemethanol, 6-[(methylamino)methyl]- | 139909-46-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-Pyridinemethanol, 6-[(methylamino)methyl]-
• 英文别名: [6-(methylaminomethyl)pyridin-2-yl]methanol
• CAS: 139909-46-9
• 化学式: C₈H₁₂N₂O
• 分子量: 152.196
• InChiKey: IGSSODKLOIGZTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  45.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Pyridinemethanol, 6-[(methylamino)methyl]- 在 氯化亚砜 作用下， 以 乙醇 为溶剂， 反应 48.0h， 生成 2-(methylaminomethyl)-6-(dimethylaminomethyl)pyridine
  参考文献：
  名称：

  Bunton, Clifford A.; Scrimin, Paolo; Tecilla, Paolo, Journal of the Chemical Society. Perkin transactions II, 1996, # 3, p. 419 - 426

  摘要：

  DOI：
• 作为产物：
  描述：

  甲胺 、 6-溴甲基-2-吡啶甲醇 以 乙醇 为溶剂， 反应 6.0h， 以82%的产率得到2-Pyridinemethanol, 6-[(methylamino)methyl]-
  参考文献：
  名称：

  Leaving group effect in the cleavage of picolinate esters catalyzed by hydroxy-functionalized metallomicelles

  摘要：

  Micellar aggregates of complexes of transition metal ions with the hydroxy-functionalized surfactant 1a are very effective catalysts of the cleavage of activated esters of alpha-amino acids. To ascertain their effectiveness toward unactivated esters, a systematic kinetic study was undertaken employing as substrates the picolinic acid esters 3a-1, the pK(a) of their alcoholic portion spanning more than 12 units from 3.6 to 16. The leaving group effect was investigated in water, pH=6.3, in the absence and presence of CU2+ ions, in the presence of the nonmicellar complex 2-CU2+, and in the presence of micellar aggregates made of 1a-Cu2+ or of its O-methylated analog 1b-Cu2+. In the presence of free metal ions the leaving group effect is negligible in the case of esters with good leaving groups (pK(a)

  DOI：

  10.1021/jo00080a006

文献信息

• Polymerization- and Solvent-Triggered Cooperativity Between Copper(II) Ions in the Catalysis of the Hydrolysis of Amino Esters by Pyridine-Based Ligands
  作者：Paolo Scrimin、Paolo Tecilla、Umberto Tonellato

  DOI：10.1002/(sici)1099-0690(199806)1998:6<1143::aid-ejoc1143>3.0.co;2-u

  日期：1998.6

  Polymeric (2) and oligomeric (4, 5) materials made of repeating units of 2,6-diaminomethylpyridine and 4,4′-diphenylmethane have been synthesized with the number of monomeric units (n) ranging from 2 to 29. In 1:1 DMSO/water solutions, these materials are fully soluble and strongly bind CuII ions. The complexes catalyze to different extents the hydrolysis of the p-nitrophenyl esters of α-, β-, and γ-amino acids

  聚合物（2）和低聚（4，5）由2,6- diaminomethylpyridine和4,4'-二苯基甲烷的重复单元的原料已经合成了与单体单元的数量（Ñ范围从2到29。1）： 1 DMSO /水溶液，这些材料是完全可溶的，并与Cu II离子牢固结合。该络合物在不同程度上催化α-，β-和γ-氨基酸的对硝基苯基酯的水解。仅利用Cu II的聚合物络合物2（Ñ ≥10）是更有效的催化剂比游离的Cu II离子在β-氨基酯的裂解中。当与单体配体（N，N'-苄基）-的Cu II配合物进行比较时，这种增强的反应性在β-丙氨酸对硝基苯酯（β-AlaPNP）的情况下几乎达到两个数量级。仅当达到一定聚合度时（6 < n <10），才在1：1（v / v）DMSO / H 2 O中观察到2,6-氨基甲基吡啶（3）。在1：1（v / v）CH 3 CH 2 OH / H 2 O中，聚合物2（n = 10）的配合物的动力学益处在9：1（v
• 2,4,6-TRIAMINO-1,3,5-TRIAZINE DERIVATIVE
  申请人：Kubota Hideki

  公开号：US20080227785A1

  公开（公告）日：2008-09-18

  This invention relates to an anti-dementia agent which uses a BEC 1 potassium channel inhibitor as the active ingredient. It was proved that the BEC 1 potassium channel inhibitor has an action to improve learning disorder and is useful as a preventive or therapeutic agent for diseases, preferably dementia, in which the BEC 1 potassium channel is considered to be concerned. Illustratively, it was confirmed by an in vivo test that the BEC 1 potassium channel inhibitor has an action to improve learning disorder. Also, it was found that a compound having 2,4,6-triamino-1,3,5-triazine has a BEC 1 potassium channel inhibitory action.

  本发明涉及一种以BEC 1钾离子通道抑制剂作为活性成分的抗痴呆剂。已经证明，BEC 1钾离子通道抑制剂具有改善学习障碍的作用，并且作为预防或治疗剂是有用的，尤其是对于BEC 1钾离子通道与之相关的疾病，如痴呆症。例如，通过体内试验证实，BEC 1钾离子通道抑制剂具有改善学习障碍的作用。此外，还发现具有2,4,6-三氨基-1,3,5-三嗪的化合物具有BEC 1钾离子通道抑制作用。
• Kinetics of "extraction" of copper(II) by micelle-solubilized complexing agents of varying hydrophilic lipophilic balance. 1. Stopped-flow study
  作者：Sung Geun Son、Marc Hebrant、Paolo Tecilla、Paolo Scrimin、Christian Tondre

  DOI：10.1021/j100205a082

  日期：1992.12

  Micellar particles can solubilize lipophilic extractants similarly to the organic phase in classical biphasic extraction. A series of 6-(alkylamino)methyl-2-(hydroxymethyl)pyridines (C(n)NHMePy with n = 1, 4, 8, 10, 12, 14, and 16), good complexing agents for copper(II), has been used in this work to investigate the role of hydrophobic interactions on the kinetics of complexation in micellar media. Apparent rate constants for complex formation (k(f)app) and dissociation (k(d)app) obtained from stopped-flow experiments are reported in different micellar systems (CTAB, SDS, and C12EO6), showing important variations with the value of n. These results which mainly concerned the protonated form of the extractant molecules (pH 3.5) have permitted precise determination of the role played by the electrostatic interactions. k(f)app is found to decrease more than 20 times in CTAB and about 10 times in C12EO6 for n changing from 1 to 16. The influence of copper(II) and surfactant concentrations on the observed rate constants is interpreted in terms of partition coefficients which have been independently determined from dialysis experiments. The reaction is found to be insensitive to surfactant concentration for n = 1, 4, and 8 in CTAB and only for n = 1 and 4 for C12EO6. The activation parameters are determined for n = 4 and 14 in water, in CTAB, and in C12EO6. The effect of the addition of alcohol and oil to form different o/w microemulsions is finally reported.
• AROMATIC NITROGENOUS SIX-MEMBERED RING COMPOUNDS
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP1219609B1

  公开（公告）日：2007-04-04
• US7375222B2
  申请人：——

  公开号：US7375222B2

  公开（公告）日：2008-05-20