Butyl phenanthren-3-yl carbonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: Butyl phenanthren-3-yl carbonate
• 英文别名: butyl phenanthren-3-yl carbonate
• 化学式: C₁₉H₁₈O₃
• 分子量: 294.3
• InChiKey: SCKNEVOUYPLPEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• ABIRATERONE AND ANALOGS THEREOF FOR THE TREATMENT OF DISEASES ASSOCIATED WITH CORTISOL OVERPRODUCTION
  申请人：Cortendo AB (publ)

  公开号：EP2945960A2

  公开（公告）日：2015-11-25
• [EN] ABIRATERONE AND ANALOGS THEREOF FOR THE TREATMENT OF DISEASES ASSOCIATED WITH CORTISOL OVERPRODUCTION<br/>[FR] ABIRATÉRONE ET SES ANALOGUES POUR LE TRAITEMENT DE MALADIES ASSOCIÉES À UNE SURPRODUCTION DE CORTISOL
  申请人：CORTENDO AB PUBL

  公开号：WO2014111815A2

  公开（公告）日：2014-07-24

  Novel analogs of abiraterone and methods of treating diseases associated with the overproduction of cortisol, such as Cushing's syndrome, obesity, headache, depression, hypertension, diabetes mellitus type II metabolic syndrome, pseudo-Cushing syndrome, cognitive impairment, dementia, heart failure, renal failure, psoriasis, glaucoma, cardiovascular disease, stroke or incidentalomas, by administering an effective amount of abiraterone or analogs thereof to a patient in need thereof are described.