3-[(R)-[(2S,6R,14S,15R)-5-(cyclopropylmethyl)-11-hydroxy-15-methoxy-16-methyl-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-16-yl]-hydroxymethyl]cyclohexa-2,4-diene-1-thione

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 3-[(R)-[(2S,6R,14S,15R)-5-(cyclopropylmethyl)-11-hydroxy-15-methoxy-16-methyl-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-16-yl]-hydroxymethyl]cyclohexa-2,4-diene-1-thione
• 化学式: C₃₁H₃₇NO₄S
• 分子量: 519.7
• InChiKey: MUMCWRZKYQVBOW-FZOOGYLASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  37
• 可旋转键数：
  5
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  94.2
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• ORVINOL AND THEVINOL DERIVATIVES USEFUL IN THE TREATMENT OF DRUG AND ALCOHOL ABUSE
  申请人：Lewis John

  公开号：US20140213603A1

  公开（公告）日：2014-07-31

  The invention provides orvinol and thevinol compounds useful for the treatment of drug and alcohol abuse, the compounds being particularly useful for the prevention of relapse in recovering addicts.

  这项发明提供了用于治疗药物和酒精滥用的奥维诺尔（orvinol）和西维诺尔（thevinol）化合物，这些化合物特别适用于预防康复成瘾者的复发。
• Orvinol and Thevinol Derivatives Useful in the Treatment of Drug and Alcohol Abuse
  申请人：The University of Bath

  公开号：US20150202200A1

  公开（公告）日：2015-07-23

  The invention provides orvinol and thevinol compounds useful for the treatment of drug and alcohol abuse, the compounds being particularly useful for the prevention of relapse in recovering addicts.
• Orvinol and Thevinol Derivatives Useful in the Treatment of Anxiety or a Compulsive Disorder
  申请人：The University of Bath

  公开号：US20160136151A1

  公开（公告）日：2016-05-19

  The invention provides a method of treating anxiety or a compulsive disorder in a subject comprising administering to the subject a compound having formula 2: or a pharmaceutically acceptable salt or solvate thereof, wherein R, R 1 , R 2 , R 3 , R 4 , R 5 , and X are as defined in the specification.
• US9051334B2
  申请人：——

  公开号：US9051334B2

  公开（公告）日：2015-06-09
• US9259422B2
  申请人：——

  公开号：US9259422B2

  公开（公告）日：2016-02-16