(6R,14S)-N-(cyclopropylmethyl)-N-ethyl-2,11-dimethoxy-14-methyl-15-oxatetracyclo[10.2.1.05,14.08,13]pentadeca-2,4,8(13),9,11-pentaen-6-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: (6R,14S)-N-(cyclopropylmethyl)-N-ethyl-2,11-dimethoxy-14-methyl-15-oxatetracyclo[10.2.1.05,14.08,13]pentadeca-2,4,8(13),9,11-pentaen-6-amine
• 化学式: C₂₃H₂₉NO₃
• 分子量: 367.5
• InChiKey: DDTCTGRSOZQUOC-HWOJSTDLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  30.9
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• ORVINOL AND THEVINOL DERIVATIVES USEFUL IN THE TREATMENT OF DRUG AND ALCOHOL ABUSE
  申请人：Lewis John

  公开号：US20140213603A1

  公开（公告）日：2014-07-31

  The invention provides orvinol and thevinol compounds useful for the treatment of drug and alcohol abuse, the compounds being particularly useful for the prevention of relapse in recovering addicts.

  这项发明提供了用于治疗药物和酒精滥用的奥维诺尔（orvinol）和西维诺尔（thevinol）化合物，这些化合物特别适用于预防康复成瘾者的复发。
• Orvinol and Thevinol Derivatives Useful in the Treatment of Drug and Alcohol Abuse, Depression, Anxiety, or a Compulsive Disorder
  申请人：The University of Bath

  公开号：US20170044173A1

  公开（公告）日：2017-02-16

  The invention provides a method of treating drug and alcohol abuse, depression, anxiety, or a compulsive disorder in a subject comprising administering to the subject a compound having formula 2 : or a pharmaceutically acceptable salt or solvate thereof, wherein R, R 1 , R 2 , R 3 , R 4 , R 5 , and X are as defined in the specification.
• US9051334B2
  申请人：——

  公开号：US9051334B2

  公开（公告）日：2015-06-09