2-acetyl-3-phenylindan-1-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 2-acetyl-3-phenylindan-1-one
• 英文别名: 2-Acetyl-3-phenyl-2,3-dihydroinden-1-one；2-acetyl-3-phenyl-2,3-dihydroinden-1-one
• 化学式: C₁₇H₁₄O₂
• 分子量: 250.297
• InChiKey: VEVACCWCBWUARA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  苯甲醛 、 1-苯基-1,3-丁二酮 在 三氯化铝 作用下， 以 various solvent(s) 为溶剂， 反应 3.0h， 生成 2-acetyl-3-phenylindan-1-one
  参考文献：
  名称：

  Selective synthesis of 1-indanones via tandem knoevenagel condensation-cycloalkylation of β-dicarbonyl compounds and aldehydes

  摘要：

  Aromatic 1,3-dicarbonyl compounds react with not enolizable aldehydes in the presence of C2H5MgBr or AlCl3 affording 2-carbethoxy- and 2-acetyl-1-indanones via tandem Knoevenagel condensation-cycloalkylation process.

  DOI：

  10.1016/0040-4020(95)00772-z

文献信息

• Friedel-crafts coordinated processes: 1-Oxoindanes from aromatic β-dicarbonyl compounds and aldehydes
  作者：Giovanni Sartori、Francia Bigi、Raimondo Maggi、Gian Luca Bernardi

  DOI：10.1016/s0040-4039(00)79324-5

  日期：1993.11

  Variously substituted 1-oxoindanes were synthesized by highly selective bis-alkylation of aromatic beta-dicarbonyl compounds with non enolizable aldehydes.
• DIFFERENTIATION MODULATING AGENTS AND USES THEREFOR
  申请人：Verva Pharmaceuticals, Inc.

  公开号：US20140221455A1

  公开（公告）日：2014-08-07

  The present invention is directed to methods and agents for modulating the differentiation potential and/or proliferation of preadipocytes. More particularly, the present invention discloses methods and agents for modulating a fibroblast growth factor (FGF) signaling pathway, especially the FGF-1 or FGF-2 signaling pathway, for treating or preventing adiposity-related conditions including, but not limited to, obesity, lipoma, lipomatosis, cachexia or lipodystrophy or the loss of adipose tissue in trauma or atrophic conditions.