11-<2-Thienyl>-undecansaeure | 26359-26-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 11-<2-Thienyl>-undecansaeure
• 英文别名: 11-Thienyl-(2)-undecansaeure；11-thiophen-2-yl-undecanoic acid；11-[2]thienyl-undecanoic acid；11-[2]Thienyl-undecansaeure；11-(2-Thienyl)undecanoic acid；11-thiophen-2-ylundecanoic acid
• CAS: 26359-26-2
• 化学式: C₁₅H₂₄O₂S
• 分子量: 268.42
• InChiKey: DEYIHTVQCPQADC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  18
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  65.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  11-<2-Thienyl>-undecansaeure 在 吡啶 、 氯化亚砜 、 乙醚 作用下， 生成 11-thiophen-2-yl-undecanoyl chloride
  参考文献：
  名称：

  Cagniant; Cagniant, Bulletin de la Societe Chimique de France, 1954, p. 1349,1353

  摘要：

  DOI：
• 作为产物：
  描述：

  10-thiophen-2-yl-decanoic acid 在 吡啶 、 氢氧化钾 、 氯化亚砜 、 乙醚 作用下， 生成 11-<2-Thienyl>-undecansaeure
  参考文献：
  名称：

  Cagniant; Cagniant, Bulletin de la Societe Chimique de France, 1954, p. 1349,1353

  摘要：

  DOI：

文献信息

• Method of inhibiting parasitic activity
  申请人：Washington University

  公开号：US05747537A1

  公开（公告）日：1998-05-05

  A method of inhibiting parasitic activity is disclosed in which the biosynthesis, structure and/or function of the glycosyl phosphatidylinositol (GPI) anchor of said parasite may be affected by incorporating into said GPI anchor selected analogs of myristic acid containing various heteroatoms, substituents and unsaturated bonds, including ester-containing analogs, ketocarbonyl-containing analogs, sulfur-containing analogs, double bond- and triple bond-containing analogs, aromatic moiety-containing analogs, nitrated analogs and halogenated analogs.

  公开了一种抑制寄生活动的方法，其中可以通过将含有各种杂原子、取代基和不饱和键的肉豆蔻酸选择性类似物纳入所述寄生物的磷脂酰肌醇糖基磷脂酰肌醇（GPI）锚中来影响所述寄生物的生物合成、结构和/或功能，其中包括酯含类似物、酮羰基含类似物、硫含类似物、双键和三键含类似物、芳香基含类似物、硝基类似物和卤代类似物。
• Methods and Systems for Making Thiol Compounds from Terminal Olefinic Compounds
  申请人：Upshaw Thomas A.

  公开号：US20090264669A1

  公开（公告）日：2009-10-22

  The application discloses thiol ester molecules and α-hydroxy thiol ester molecules having a thiol group located on one of the final two carbon atoms in a carbon chain or a terminal or α-hydroxyl groups, respectively. The disclosed thiol ester molecules and or α-hydroxyl thiol ester molecules es may be made from unsaturated ester molecules having one or more terminal alkene groups. The disclosed techniques also provide methods for making unsaturated ester molecules having one or more terminal alkene groups by the metathesis of unsaturated esters having one or more internal carbon-carbon double bonds (e.g. natural source oils). The thiol ester molecules or α-hydroxy thiol ester molecule may be used in reactions with isocyanate monomers, epoxide monomer, or material having multiple alkene groups to make sealants, coatings, adhesives, and other products.

  本发明揭示了具有巴豆醇基位于碳链的最后两个碳原子之一或具有末端或α-羟基的巴豆醇酯分子和α-羟基巴豆醇酯分子。所述的巴豆醇酯分子或α-羟基巴豆醇酯分子可以由具有一个或多个末端烯烃基团的不饱和酯分子制备而成。本发明还提供了通过不饱和酯类之间的交换反应（例如天然源油）制备具有一个或多个末端烯烃基团的不饱和酯分子的方法。巴豆醇酯分子或α-羟基巴豆醇酯分子可以与异氰酸酯单体，环氧单体或具有多个烯烃基团的材料反应，制备密封剂，涂料，粘合剂和其他产品。
• Thienyl-containing fatty acid glycosyl phosphatidylinosital analogues
  申请人：Washington University

  公开号：US05998642A1

  公开（公告）日：1999-12-07

  A method of inhibiting parasitic activity is disclosed in which the biosynthesis, structure and/or function of the glycosyl phosphatidylinositol (GPI) anchor of said parasite may be affected by incorporating into said GPI anchor selected analogs of myristic acid containing various heteroatoms, substituents and unsaturated bonds, including ester-containing analogs, ketocarbonyl-containing analogs, sulfur-containing analogs, double bond- and triple bond-containing analogs, aromatic moiety-containing analogs, nitrated analogs and halogenated analogs.

  本发明揭示了一种抑制寄生虫活动的方法，其中可以通过将所述GPI锚中选择的肉豆蔻酸类似物包含其中来影响所述寄生虫的生物合成、结构和/或功能，所述肉豆蔻酸类似物包括含有各种杂原子、取代基和不饱和键的酯类类似物、酮羰基类类似物、含硫类类似物、双键和三键含有类类似物、芳香基含有类类似物、硝基类类似物和卤代类类似物。
• Tetradecadienoic acid, a glycosyl phosphatidylinositol (GPI) analogue
  申请人：Washington University

  公开号：US05760259A1

  公开（公告）日：1998-06-02

  A method of inhibiting parasitic activity is disclosed in which the biosynthesis, structure and/or function of the glycotyl phosphatidylinositol (GPI) anchor of said parasite may be affected by incorporating into said GPI anchor selected analogs of myristic acid containing various heteroatoms, substituents and unsaturated bonds, including ester-containing analogs, ketocarbonyl-containing analogs, sulfur-containing analogs, double bond- and triple bond-containing analogs, aromatic moiety-containing analogs, nitrated analogs and halogenated analogs.

  本发明揭示了一种抑制寄生活动的方法，其中可以通过将所选肉豆蔻酸的类似物包含到所述寄生物的糖脂磷酰肌醇（GPI）锚中，影响所述 GPI 锚的生物合成、结构和/或功能，其中所选肉豆蔻酸的类似物包括含有各种杂原子、取代基和不饱和键的酯类类似物、酮基含量类似物、硫含量类似物、双键和三键含量类似物、芳香基团含量类似物、硝基类似物和卤代类似物。
• Furyl containing fatty acids, glycosyl phosphatidylinositol (GPI)
  申请人：Washington University

  公开号：US06048989A1

  公开（公告）日：2000-04-11

  A method of inhibiting parasitic activity is disclosed in which the biosynthesis, structure and/or function of the glycosyl phosphatidylinositol (GPI) anchor of said parasite may be affected by incorporating into said GPI anchor selected analogs of myristic acid containing various heteroatoms, substituents and unsaturated bonds, including ester-containing analogs, ketocarbonyl-containing analogs, sulfur-containing analogs, double bond- and triple bond-containing analogs, aromatic moiety-containing analogs, nitrated analogs and halogenated analogs.

  本发明揭示了一种抑制寄生活动的方法，其中通过将所选肉豆蔻酸的类似物纳入所述寄生物的磷脂酰肌醇醇磷脂（GPI）锚定物中，影响所述寄生物的GPI锚定物的生物合成、结构和/或功能，所述类似物包括含有各种杂原子、取代基和不饱和键的肉豆蔻酸酯类似物、酮羰基含有类似物、含硫类似物、双键和三键含有类似物、芳香基团含有类似物、硝化类似物和卤代类似物。