Methyl 2-[1-(acetamidomethyl)cyclohexyl]acetate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Methyl 2-[1-(acetamidomethyl)cyclohexyl]acetate
• 英文别名: methyl 2-[1-(acetamidomethyl)cyclohexyl]acetate
• 化学式: C₁₂H₂₁NO₃
• 分子量: 227.3
• InChiKey: WDWOPNNKMMSRBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• C-HALOGEN BOND FORMATION
  申请人：The Trustees of Princeton University

  公开号：US20150031768A1

  公开（公告）日：2015-01-29

  Methods of halogenating a carbon containing compound having an sp3 C—H bond are provided. Methods of fluorinating a carbon containing compound comprising halogenation with Cl or Br followed by nucleophilic substitution with F are provided. Methods of direct oxidative C—H fluorination of a carbon containing compound having an sp3 C—H bond are provided. The halogenated products of the methods are provided.

  提供了卤代含有sp3 C—H键的碳化合物的卤化方法。提供了卤代含碳化合物的氟化方法，其中包括使用Cl或Br进行卤化，然后进行亲核取代反应以得到F。提供了直接氧化C—H氟化含有sp3 C—H键的碳含量化合物的方法。提供了这些方法的卤代产物。
• C-halogen bond formation
  申请人：Groves John T.

  公开号：US10196341B2

  公开（公告）日：2019-02-05

  Methods of halogenating a carbon containing compound having an sp3 C—H bond are provided. Methods of fluorinating a carbon containing compound comprising halogenation with Cl or Br followed by nucleophilic substitution with F are provided. Methods of direct oxidative C—H fluorination of a carbon containing compound having an sp3 C—H bond are provided. The halogenated products of the methods are provided.

  提供了卤化具有 sp3 C-H 键的含碳化合物的方法。提供了含碳化合物的氟化方法，包括先用 Cl 或 Br 卤化，再用 F 亲核取代。提供了具有 sp3 C-H 键的含碳化合物的直接氧化 C-H 氟化方法。提供了这些方法的卤化产物。
• [EN] C-HALOGEN BOND FORMATION<br/>[FR] FORMATION D'UNE LIAISON C-HALOGÈNE
  申请人：UNIV PRINCETON

  公开号：WO2015054476A1

  公开（公告）日：2015-04-16

  Methods of halogenating a carbon containing compound having an sp3 C-H bond are provided. Methods of fluorinating a carbon containing compound comprising halogenation with Cl or Br followed by nucleophilic substitution with F are provided. Methods of direct oxidative C-H fluorination of a carbon containing compound having an sp3 C-H bond are provided. The halogenated products of the methods are provided.