2,6-Diaminohexanoic acid;2-[4-oxo-3-[[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl]phthalazin-1-yl]acetic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2,6-Diaminohexanoic acid;2-[4-oxo-3-[[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl]phthalazin-1-yl]acetic acid
• 英文别名: 2,6-diaminohexanoic acid;2-[4-oxo-3-[[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl]phthalazin-1-yl]acetic acid
• 化学式: C25H26F3N5O5S
• 分子量: 565.6
• InChiKey: IFUZARDALJIFSZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.23
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  200
• 氢给体数：
  4
• 氢受体数：
  13

文献信息

• WATER SOLUBLE SALTS OF ALDOSE REDUCTASE INHIBITORS FOR TREATMENT OF DIABETIC COMPLICATIONS
  申请人：Mylari Banavara L.

  公开号：US20140228319A1

  公开（公告）日：2014-08-14

  The present invention relates to pharmaceutically acceptable water soluble salts of aldose reductase inhibitors, 2-(8-oxo-7-((5-trifluromethyl)-1H-benzo[d]imidazol-2-yl)methyl)7,8-dihydropyrazin[2,3-d]pyridazin-5-yl)acetic acid and [4-oxo-(5-trifluoromethyl-benzothaiazol-2-ylmethyl)-3,4-dihydro-phthalazin-1-yl]-acetic acid (also known as zopolrestat), pharmaceutical compositions thereof and methods of treating diabetic complications in mammals comprising administering to mammals these salt and compositions.
• [EN] WATER SOLUBLE SALTS OF ALDOSE REDUCTASE INHIBITORS FOR TREATMENT OF DIABETIC COMPLICATIONS<br/>[FR] SELS SOLUBLES DANS L'EAU D'INHIBITEURS D'ALDOSE RÉDUCTASE POUR LE TRAITEMENT DE COMPLICATIONS DIABÉTIQUES
  申请人：MYLARI BANAVARA L

  公开号：WO2014126885A1

  公开（公告）日：2014-08-21

  The present invention relates to pharmaceutically acceptable water soluble salts of aldose reductase inhibitors, 2-(8~oxo~7~((5~trifiuromethyl)-I H-benzo[d] imidayol-2-yl)methyl)7,8- dihydropyrazin[2,3-d]pyridazin~5-yl)acetic acid and [4-oxo-(5-trifluoromethyl-benzothaiazol-2- ylmethyl)-3,4-dihydro-phthalazin-I -yl]-acetic acid (also known as zopolrestat), pharmaceutical compositions thereof and methods of treating diabetic complications in mammals comprising administering to mammals these salt and compositions.