Butyliden-(2)-malonsaeure-dimethylester | 18795-89-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Butyliden-(2)-malonsaeure-dimethylester
• 英文别名: Dimethyl 2-butan-2-ylidenepropanedioate
• CAS: 18795-89-6
• 化学式: C₉H₁₄O₄
• 分子量: 186.208
• InChiKey: FECVTCNHKAFBFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Butyliden-(2)-malonsaeure-dimethylester 在 水 作用下， 生成 (Z)-2-(Methoxycarbonyl)-3-methylpent-2-enoic acid 、 (E)-2-(Methoxycarbonyl)-3-methylpent-2-enoic acid
  参考文献：
  名称：

  Enzyme-catalyzed hydrolyses of E/Z-diastereotopic and E/Z-diastereomeric esters. Effect on selectivity by reaction media

  摘要：

  PLE-catalyzed hydrolyses of different types of E/Z-diastereotopic diesters and E/Z-diastereomeric monoesters have been studied. Arylidenepropanedioic diesters are specifically hydrolyzed to the Z-half esters, whereas the de values for dialkylated methylene propanedioic diesters range between 33 and 79% (Z). D values for the hydrolyses of the 3-methyleneazetidin-2-ones in detergent-buffer systems depend on the size of the substituent in the alpha-position. Diastereoselectivity of these substrates is affected by addition of the cosolvents acetonitrile and methanol.

  DOI：

  10.1021/jo00070a015
• 作为产物：
  描述：

  4-ethyl-4,5-dihydro-pyrazole-3,3-dicarboxylic acid dimethyl ester 以 xylene 为溶剂， 生成 Butyliden-(2)-malonsaeure-dimethylester
  参考文献：
  名称：

  Danion-Bougot,R.; Carrie,R., Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1968, vol. 266, p. 645 - 648

  摘要：

  DOI：

文献信息

• [EN] THIADIAZOLYL-OXIMINOACETIC ACID DERIVATIVE COMPOUNDS<br/>[FR] COMPOSÉS DÉRIVÉS DE L'ACIDE THIADIAZOLYL-OXYMINOACÉTIQUE
  申请人：MERCK SHARP & DOHME

  公开号：WO2016100897A1

  公开（公告）日：2016-06-23

  Thiadiazolyl-oximinoacetic acid derivatives have been synthesized, which are useful in the manufacture of cephalosporin antibiotic compounds. Compound (1 ) (TATD) is commercially available (CAS No. 76028-96-1 ). It has now been discovered that the thiadiazolyl-oximinoacetic acid derivative compound (1 ) (TATD) can be prepared from dimethyl malonate (SM 1, CAS No. 108-59-8) according to methods described herein. The methods provide products having desirable purity.

  已经合成了噻二唑基-肟基乙酸衍生物，这些衍生物在头孢菌素抗生素化合物的制造中很有用。化合物（1）（TATD）商业上可获得（CAS号76028-96-1）。现在发现，根据本文所述的方法，可以从二甲基丙二酸酯（SM 1，CAS号108-59-8）制备噻二唑基-肟基乙酸衍生物化合物（1）（TATD）。这些方法提供具有理想纯度的产品。
• SOLID CATALYST COMPONENT FOR OLEFIN POLYMERIZATION, CATALYST FOR OLEFIN POLYMERIZATION, AND METHOD FOR PRODUCING OLEFIN POLYMER
  申请人：Uozumi Toshiya

  公开号：US20140221583A1

  公开（公告）日：2014-08-07

  An olefin polymer that is obtained using an olefin polymerization catalyst that includes a solid catalyst component for olefin polymerization that includes titanium, magnesium, a halogen, and an ester compound (A) represented by the following formula (1): R 1 R 2 C═C(COOR 3 )(COOR 4 ), an organoaluminum compound, and an optional external electron donor compound, exhibits primary properties (e.g., molecular weight distribution and stereoregularity) similar to those of an olefin polymer obtained using a solid catalyst component that includes a phthalic ester as an electron donor.

  使用一种包括钛、镁、卤素和酯化合物(A)的固体催化剂组分（式子1：R1R2C═C(COOR3)(COOR4)）进行烯烃聚合得到的烯烃聚合物，加上有机铝化合物和可选的外部电子给体化合物，表现出与包括邻苯二甲酸酯作为电子给体的固体催化剂组分得到的烯烃聚合物相似的主要性质（如分子量分布和立构规则性）。
• Method for producing solid catalyst component for olefin polymerization, catalyst for olefin polymerization and a process for propylene polymerization
  申请人：TOHO TITANIUM CO., LTD.

  公开号：US10246530B2

  公开（公告）日：2019-04-02

  A method for producing a solid catalyst for olefin (co)polymerization includes bringing into contact with each other a magnesium compound, a tetravalent titanium halide compound, an organic compound represented the following general formula (1) R1k(C6H4-k)(COOR2)(COOR3)  (1) and an organic compound represented the following general formula (2) R4R5C═C (COOR6)(COOR7)  (2) wherein R1 is a halogen atom or an alkyl group, R2 and R3 are a linear alkyl group, R4 and R5 are independently an atom or group selected from a hydrogen atom, halogen, a linear alkyl group, a branched alkyl group a vinyl group, a linear or branched alkenyl group, a cycloalkenyl group, an aromatic hydrocarbon group, and R6 and R7 are independently a linear alkyl group, a branched alkyl group, a vinyl group, a linear or branched alkenyl group a cycloalkyl group, a cycloalkenyl group, or an aromatic hydrocarbon group.

  一种生产烯烃（共）聚合用固体催化剂的方法，包括使镁化合物、四价卤化钛化合物、下 列通式（1）代表的有机化合物相互接触 R1k(C6H4-k)(COOR2)(COOR3) (1) 和 代表以下通式(2)的有机化合物 R4R5C═C (COOR6)(COOR7) (2) 其中 R1 是卤素原子或烷基，R2 和 R3 是直链烷基，R4 和 R5 独立地是选自氢原子、卤素、直链烷基、支链烷基、乙烯基、直链或支链烯基、环烯基、芳香烃基的原子或基团，R6 和 R7 独立地是直链烷基、支链烷基、乙烯基、直链或支链烯基、环烷基、环烯基或芳香烃基。
• Electrochemically induced oxidative rearrangement of alkylidenemalonates
  作者：Michail N Elinson、Sergey K Feducovich、Gennady I Nikishin

  DOI：10.1016/s0040-4020(98)00912-0

  日期：1998.11

  Alkylidenemalonates capable of double bond migration being electrolyzed in methanol or ethanol in the presence of alkali metal halides in an undivided cell equipped with Fe cathode are transformed into 2-alkyl-3,3-dimethoxyalkane-1,1-dicarboxylates in 70-90% yield via electrochemically induced oxidative rearrangement. Acidification of the reaction mixture after the electrolysis leads to the formation of 2-alkyl-3-oxoalkane-1,1-dicarboxylates. In the case of isobutylidenemalonate, the electrolysis intermediate dimethyl 3,3-dimethyl-2-methoxycyclopropane-1,1-dicarboxylate was isolated in 70% yield. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.
• METHOD FOR PRODUCING SOLID CATALYST COMPONENT FOR OLEFIN POLYMERIZATION, CATALYST FOR OLEFIN POLYMERIZATION AND A PROCESS FOR PROPYLENE POLYMERIZATION
  申请人：Toho Titanium Co., Ltd.

  公开号：EP3645586A1

  公开（公告）日：2020-05-06