hexanoic acid, undecyl ester | 103677-76-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: hexanoic acid, undecyl ester
• 英文别名: Undecyl hexanoate
• CAS: 103677-76-5
• 化学式: C₁₇H₃₄O₂
• 分子量: 270.456
• InChiKey: PCUSXIRIPAHAHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  19
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  dodecanoyl hexanoyl peroxide 以1%的产率得到
  参考文献：
  名称：

  FELDHUES, M.;SCHAEFER, H. J., TETRAHEDRON, 1985, 41, N 19, 4195-4212

  摘要：

  DOI：

文献信息

• [EN] POLYNUCLEOTIDES ENCODING JAGGED1 FOR THE TREATMENT OF ALAGILLE SYNDROME<br/>[FR] POLYNUCLÉOTIDES CODANT POUR JAGGED1 POUR LE TRAITEMENT DU SYNDROME D'ALAGILLE
  申请人：MODERNATX INC

  公开号：WO2017201342A1

  公开（公告）日：2017-11-23

  The invention relates to mRNA therapy for the treatment of Alagille syndrome (ALGS), mRNAs for use in the invention, when administered in vivo, encode JAGGED 1 (JAG1), isoforms thereof, functional fragments thereof, and fusion proteins comprising JAG1, mRNAs of the invention are preferably encapsulated in lipid nanoparticles (LNPs) to effect efficient delivery to cells and/or tissues in subjects, when administered thereto. mRNA therapies of the invention increase and/or restore deficient levels of JAG1 expression and/or activity in subjects. mRNA therapies of the invention further decrease levels of toxic metabolites associated with deficient JAG1 activity in subjects.

  该发明涉及用于治疗艾拉吉尔综合征（ALGS）的mRNA疗法，该发明中使用的mRNA，在体内给予时，编码JAGGED 1（JAG1）、其同工异构体、其功能性片段以及包含JAG1的融合蛋白，该发明的mRNA最好被封装在脂质纳米颗粒（LNPs）中，以实现对受试者的细胞和/或组织的有效传递，当向受试者施用时。该发明的mRNA疗法增加和/或恢复受试者中JAG1表达和/或活性的不足水平。该发明的mRNA疗法进一步降低与受试者中JAG1活性不足相关的有毒代谢物水平。
• Coloring-time controlling layer
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0203776A2

  公开（公告）日：1986-12-03

  Disclosed herein is a coloring-time controlling layer suitable for use in a temperature-control indicator unit. The coloring-time controlling layer is composed of a film obtained by drying an emulsion of a polymer containing styrene and/or acrylonitrile as constituent unit(s) and interposed between [A] a layer containing microcapsules of an oily substance and [B] another layer containing a substance capable of inducing coloring upon contact with the oily substance. In a preferred embodiment, the coloring-time controlling layer is used for a temperature-control indicator unit comprising microcapsules containing a hydrophobic organic compound having a desired melting point, a methine-type dyestuff precursor and an oxidizing substance.

  本文公开了一种适用于温度控制指示装置的着色时间控制层。该着色时间控制层由一层薄膜组成，该薄膜是通过干燥以苯乙烯和/或丙烯腈为组成单元的聚合物乳液而获得的，它被夹在[A]一层含有油性物质微胶囊的层和[B]另一层含有与油性物质接触后能引起着色的物质的层之间。在一个优选的实施方案中，着色时间控制层用于温度控制指示器单元，该单元由微胶囊组成，微胶囊含有具有所需熔点的疏水性有机化合物、甲烷型染料前体和氧化物质。
• [EN] REVERSIBLE THERMAL DISCOLORATION AQUEOUS INK COMPOSITION AND WRITING IMPLEMENT USING THE SAME AND WRITING IMPLEMENT SET<br/>[FR] COMPOSITION D'ENCRE AQUEUSE À DÉCOLORATION THERMIQUE RÉVERSIBLE ET INSTRUMENT D'ÉCRITURE UTILISANT CELLE-CI ET ENSEMBLE INSTRUMENT D'ÉCRITURE
  申请人：PILOT INK CO LTD

  公开号：WO2009107855A1

  公开（公告）日：2009-09-03

  To provide a reversible thermal discoloration aqueous ink composition which is capable of suppressing the lightening and deepening of handwriting at the time when a writing implement containing the reversible thermal discoloration aqueous ink composition in the barrel, and particularly, which does not lighten the color of handwriting with time in an erecting state or does not lighten the color of handwriting by the application of vibration at transportation or at the time when it is carried on in an erecting state, as well as a writing implement using the same and a writing implement set. A reversible thermal discoloration aqueous ink composition comprising water, a reversible thermal discoloration microcapsule pigment including a reversible thermal discoloration composition composed of (A) an electron donative coloring organic compound, (B) an electron accepting compound and (C) a reaction medium which determines a temperature at which color reactions of the both compounds occur, a polymer flocculant, a comb-type polymer dispersant having a carboxyl group at the side chain, an organic nitrogen sulfur compound, and a water-soluble resin; a writing implement 1 using the ink composition; and a writing implement set comprising the writing implement and a frictional body.

  一种可逆热变色水性墨水组合物，其在书写工具的笔杆中包含可逆热变色水性墨水组合物时，能够抑制书写颜色的变浅和加深，特别地，在竖直状态下的书写颜色不随着时间变浅，或在运输过程中或在竖直状态下书写颜色不因振动而变浅；以及使用该墨水组合物的书写工具和书写工具组。所述可逆热变色水性墨水组合物包括水、可逆热变色微胶囊颜料(包括由(A)供电子着色有机化合物、(B)受电子化合物和(C)确定两种化合物发生颜色反应的温度的反应介质组成的可逆热变色组合物)、聚合物絮凝剂、侧链带有羧基的梳型聚合物分散剂、有机氮硫化合物和水溶性树脂。使用所述墨水组合物的书写工具1；以及包括所述书写工具和摩擦体的书写工具组。
• HERBICIDAL COMPOSITIONS
  申请人：KVK AGRO A/S

  公开号：EP0639047A1

  公开（公告）日：1995-02-22
• STABILIZED HERBICIDE COMPOSITIONS
  申请人：KVK AGRO A/S

  公开号：EP0637910A1

  公开（公告）日：1995-02-15