erythro-3-methoxy-2-methyl-1-phenyl-1-propanol | 57051-07-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: erythro-3-methoxy-2-methyl-1-phenyl-1-propanol
• 英文别名: (1R,2S)-3-methoxy-2-methyl-1-phenylpropan-1-ol
• CAS: 57051-07-7；84784-80-5；84784-85-0
• 化学式: C₁₁H₁₆O₂
• 分子量: 180.247
• InChiKey: VTBVRCTZGIEDOK-GXSJLCMTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  erythro-3-methoxy-2-methyl-1-phenyl-1-propanol 在 jones reagent 作用下， 以 丙酮 为溶剂， 反应 0.13h， 以91%的产率得到3-methoxy-2-methyl-1-phenylpropan-1-one
  参考文献：
  名称：

  Nakata, Tadashi; Tani, Yoichiro; Hatozaki, Masayoshi, Chemical and pharmaceutical bulletin, 1984, vol. 32, # 4, p. 1411 - 1415

  摘要：

  DOI：
• 作为产物：
  描述：

  ethyl (2R*,3R*)-3-hydroxy-2-methyl-3-phenylpropanoate 在 盐酸 、 sodium hydroxide 、 lithium aluminium tetrahydride 、 水 、 potassium hydride 、 对甲苯磺酸 作用下， 以 四氢呋喃 、 甲醇 、 正己烷 、 水 为溶剂， 反应 71.25h， 生成 erythro-3-methoxy-2-methyl-1-phenyl-1-propanol
  参考文献：
  名称：

  Nakata, Tadashi; Tani, Yoichiro; Hatozaki, Masayoshi, Chemical and pharmaceutical bulletin, 1984, vol. 32, # 4, p. 1411 - 1415

  摘要：

  DOI：

文献信息

• Antipruritics
  申请人：Yasui Kiyoshi

  公开号：US20080312292A1

  公开（公告）日：2008-12-18

  It is intended to provide antipruritics (drugs to control itching, antiitch agents and drugs to stop itching). It is found out that a compound having an agonistic activity to the cannabinoid receptor shows an antipruritics effect.

  这句话的意思是：它旨在提供止痒药（控制瘙痒的药物、抗瘙痒剂和止痒药物）。发现一种具有类脂激素受体激动活性的化合物具有止痒效果。
• Pyridone derivatives having a binding activity to the cannabinoid type 2 recepter
  申请人：TADA Yukio

  公开号：US20100081686A1

  公开（公告）日：2010-04-01

  It was found that the compound having a binding activity to the cannabinoid type 2 receptor represented by the formula (I): wherein R 1 is a group represented by the formula: —Y 1 —Y 2 —Y 3 —R a wherein Y 1 is single bond or the like; Y 2 is —C(═O)—NH— or the like; Y 3 is optionally substituted aryl or the like; R 2 is hydrogen or the like; R 3 is alkyl or the like; R 4 is alkyl or the like; R 5 is optionally substituted alkyl or the like; or R 3 and R 4 taken together with the adjacent atom form cyclic group or the like.

  发现化合物具有与cannabinoid type 2受体结合活性，该化合物的公式为（I）：其中R1是由公式表示的基团：—Y1—Y2—Y3—Ra，其中Y1是单键或类似物；Y2是—C（═O）—NH—或类似物；Y3是可选择的取代芳基或类似物；R2是氢或类似物；R3是烷基或类似物；R4是烷基或类似物；R5是可选择的取代烷基或类似物；或R3和R4与相邻原子结合形成环状基团或类似物。
• Cyclic Amine Compound and Use Thereof for the Prophylaxis or Treatment of Hypertension
  申请人：Kuroita Takanobu

  公开号：US20100121048A1

  公开（公告）日：2010-05-13

  The present invention relates to a compound represented by the formula: (I) wherein ring A is a 5- or 6-membered aromatic heterocycle optionally having substituent (s); U, V and W are each independently C or N, provided that when any one of U, V and W is N, then the others should be C; Ra and Rb are each independently a cyclic group optionally having substituent(s), a C 1-10 alkyl group optionally having substituent(s), a C 2-10 alkenyl group optionally having substituent(s), or a C 2-10 alkynyl group optionally having substituent(s); X is a bond, or a spacer having 1 to 6 atoms in the main chain; Y is a spacer having 1 to 6 atoms in the main chain; Rc is a hydrocarbon group optionally containing heteroatom(s) as the constituting atom(s), which optionally has substituent(s); m and n are each independently 1 or 2; and ring B optionally further has substituent(s), or a salt thereof. The compound of the present invention has excellent renin inhibitory activity, and thus is useful as an agent for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension, and the like.

  本发明涉及一种由式(I)表示的化合物：其中，环A是一种5或6成员的芳香杂环，可选地具有取代基；U、V和W分别独立地为C或N，但当U、V和W中的任何一个为N时，其他的应为C；Ra和Rb分别独立地为一个环状基团，可选地具有取代基；一个C1-10烷基，可选地具有取代基；一个C2-10烯基，可选地具有取代基；或一个C2-10炔基，可选地具有取代基；X是一条键或具有1到6个原子的主链间隔；Y是具有1到6个原子的主链间隔；Rc是一个含有杂原子作为构成原子的碳氢基团，可选地具有取代基；m和n分别独立地为1或2；环B可选地具有取代基，或其盐。本发明的化合物具有优异的肾素抑制活性，因此可用作预防或治疗高血压、高血压引起的各种器官损伤等的药物。
• Pentacoordinate vs. Tetracoordinate complexation for alkoxycarbonyl compounds with dialkylboron triflates and trifluoroacetates ?
  作者：Takashi Ooi、Daisuke Uraguchi、Keiji Maruoka

  DOI：10.1016/s0040-4039(98)01798-5

  日期：1998.10

  The implication of hitherto unknown pentacoordinate complex formation for alkoxycarbonyl compounds with Et2BX (X = OTf, OCOCF3) is presented by several reduction/allylation experiments and low-temperature C-13, B-11 NMR spectroscopy. (C) 1998 Elsevier Science Ltd. All rights reserved.
• NAKATA, TADASHI;TANI, YOICHIRO;HATOZAKI, MASAYOSHI;OISHI, TAKESHI, CHEM. AND PHARM. BULL., 1984, 32, N 4, 1411-1415
  作者：NAKATA, TADASHI、TANI, YOICHIRO、HATOZAKI, MASAYOSHI、OISHI, TAKESHI

  DOI：——

  日期：——