2-Chrysen-3-yl-2-propylpropanedioic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 2-Chrysen-3-yl-2-propylpropanedioic acid
• 英文别名: 2-chrysen-3-yl-2-propylpropanedioic acid
• 化学式: C₂₄H₂₀O₄
• 分子量: 372.4
• InChiKey: YININEWMUUJQCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• C-3 ALKYL AND ALKENYL MODIFIED BETULINIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF HIV
  申请人：Bristol-Myers Squibb Company

  公开号：EP2958930A1

  公开（公告）日：2015-12-30
• [EN] C-3 ALKYL AND ALKENYL MODIFIED BETULINIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF HIV<br/>[FR] DÉRIVÉS D'ACIDE BÉTULINIQUE MODIFIÉS PAR ALKYLE ET ALCÉNYLE EN C-3 UTILES DANS LE TRAITEMENT DU VIH
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2014130810A1

  公开（公告）日：2014-08-28

  Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, alkyl and alkenyl C-3 modified betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II, III and IV: a compound of Formula I; a compound of Formula II; a compound of Formula III: and a compound of Formula IV. These compounds are useful for the treatment of HIV and AIDS.