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3-Hydroxy-4-methylidene-2-(propan-2-ylamino)cyclobut-2-en-1-one

中文名称
——
中文别名
——
英文名称
3-Hydroxy-4-methylidene-2-(propan-2-ylamino)cyclobut-2-en-1-one
英文别名
3-hydroxy-4-methylidene-2-(propan-2-ylamino)cyclobut-2-en-1-one
3-Hydroxy-4-methylidene-2-(propan-2-ylamino)cyclobut-2-en-1-one化学式
CAS
——
化学式
C8H11NO2
mdl
——
分子量
153.18
InChiKey
WXRMVETUUUMILD-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    1.2
  • 重原子数:
    11
  • 可旋转键数:
    2
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.38
  • 拓扑面积:
    49.3
  • 氢给体数:
    2
  • 氢受体数:
    3

文献信息

  • Substituted Pyrrolidines and Methods of Use
    申请人:AbbVie S.à.r.l.
    公开号:US20180099931A1
    公开(公告)日:2018-04-12
    The invention discloses compounds of Formula (I) wherein R 1 , R 2 , R 2A , R 3 , R 3A , R 4 , R 4A , and R 5 are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.
    该发明公开了式(I)的化合物 其中R 1 ,R 2 ,R 2A ,R 3 ,R 3A ,R 4 ,R 4A 和R 5 如本文所定义。本发明涉及化合物及其在囊性纤维化治疗中的应用,其生产方法,包含相同化合物的药物组合物,以及通过给予该发明的化合物来治疗囊性纤维化的方法。
  • CYCLOSPORIN DERIVATIVES
    申请人:Fischer Gunter
    公开号:US20140316104A1
    公开(公告)日:2014-10-23
    The present invention relates to novel cyclosporin derivatives that do not cross the cellular membrane. The compounds according to the invention are used in medicine, more particularly in the treatment/diagnosis of acute and chronic inflammatory diseases, viral infections, cancer, degenerative muscle diseases, neurodegenerative diseases and damage that is associated with calcium homeostasis impairment. The novel cyclosporin derivatives additionally have no immunosuppressive effect.
    本发明涉及一种新型环孢霉素衍生物,其不穿过细胞膜。本发明的化合物用于医学,特别是用于治疗/诊断急性和慢性炎症性疾病、病毒感染、癌症、退行性肌肉疾病、神经退行性疾病以及与钙稳态障碍相关的损伤。这些新型环孢霉素衍生物还没有免疫抑制作用。
  • SORBENT COMPRISING AN AROMATIC RING SYSTEM ON ITS SURFACE FOR THE PURIFICATION OF ORGANIC MOLECULES
    申请人:INSTRACTION GMBH
    公开号:US20140243512A1
    公开(公告)日:2014-08-28
    In a first embodiment the present invention relates to a sorbent comprising a porous inorganic solid support material having on its surface a film of a crosslinked polyvinylamine comprising derivatized amine groups and amine groups binding to the surface of the support material via electron donor/acceptor interactions. In a second embodiment the present invention relates to a sorbent comprising a solid support material, the surface of which comprises a residue of a general formula (I), wherein the residue is attached via a covalent single bond to a functional group on the surface of either the bulk solid support material itself or of a polymer film on the surface of the solid support material. Furthermore, the present invention relates to the use of the sorbents according to the invention for the purification of organic molecules, in particular pharmaceutical active compounds, preferably in chromatographic applications.
  • SORBENT COMPRISING ON ITS SURFACE AN AROMATIC RING SYSTEM HAVING AN ANIONIC OR DEPROTONIZABLE GROUP FOR THE PURIFICATION OF ORGANIC MOLECULES
    申请人:INSTRACTION GMBH
    公开号:US20150045545A1
    公开(公告)日:2015-02-12
    The present invention relates to a sorbent comprising a solid support material, the surface of which comprises a residue of a general formula (I), wherein the residue is attached via a covalent single bond to a functional group on the surface of either the bulk solid support material itself or of a polymer film on the surface of the solid support material. Furthermore, the present invention relates to the use of the sorbent according to the invention for the purification of organic molecules, in particular pharmaceutically active compounds, preferably in chromatographic applications.
  • US9453051B2
    申请人:——
    公开号:US9453051B2
    公开(公告)日:2016-09-27
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同类化合物

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