Tetramethylthiacycloheptyne

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: Tetramethylthiacycloheptyne
• 英文别名: 3,3,4,4-tetramethyl-1λ4-thiacycloheptyne
• 化学式: C₁₀H₁₈S
• 分子量: 170.32
• InChiKey: XMMFNCYXVKBUEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• REACTIVE LABELLING COMPOUNDS AND USES THEREOF
  申请人：Academia Sinica

  公开号：US20150309041A1

  公开（公告）日：2015-10-29

  Provided are azido-BODIPY compounds of formula (I), cyclooctyne-based fluorogenic probes of formula (IV), and activity-based probes of formula (VI). These compounds undergo azide alkyne cycloadditions (AAC) with to form triazolyl products. The provided compounds are useful for detection and imaging of alkyne-, or azide-containing molecules. Methods for detection and imaging biomolecules using compounds of the present disclosure are disclosed.

  提供的是式（I）的叠氮基BODIPY化合物、式（IV）的环辛炔基荧光探针，以及式（VI）的活性探针。这些化合物通过叠氮-炔烃环加成反应（AAC）形成三唑基产物。提供的化合物可用于检测和成像含炔基或叠氮基的分子。本公开的方法揭示了利用本公开的化合物检测和成像生物分子的方法。
• Iminosydnone derivatives for conjugation and release of compounds of interest
  申请人：L'Universite de Strasbourg

  公开号：EP2957559A1

  公开（公告）日：2015-12-23

  The present invention relates to the use of iminosydnone compounds in processes for the preparation of conjugates of two compounds of interest. The invention further relates to the use of said iminosydnone compounds in a process for releasing a third compound of interest. The invention finally relates to said new iminosydnone compounds.

  本发明涉及使用亚胺硝基化合物在制备两种感兴趣化合物的结合物的过程中的应用。本发明还涉及使用上述亚胺硝基化合物在释放第三种感兴趣化合物的过程中的应用。最后，本发明涉及这些新的亚胺硝基化合物。
• PROTEIN COMPLEX USING FATTY ACID DERIVATIVE, AND PREPARATION METHOD THEREFOR
  申请人：Hanmi Pharm. Co., Ltd.

  公开号：EP3384935A1

  公开（公告）日：2018-10-10

  The present invention relates to a protein conjugate in which a physiologically active polypeptide and a biocompatible material are linked through a fatty acid derivative, thus having an extended duration of physiological activity compared to that of a natural type, and a method of preparing the same. The protein conjugate of the present invention in which a biocompatible material, fatty acid, and a physiologically active polypeptide are linked was confirmed to have an increased half-life of the physiologically active polypeptide, and thus can be widely used in the field of protein drugs.

  本发明涉及一种蛋白质共轭物，其中生理活性多肽和生物相容性材料通过脂肪酸衍生物连接在一起，因此与天然类型的蛋白质共轭物相比具有更长的生理活性持续时间，本发明还涉及制备这种蛋白质共轭物的方法。经证实，本发明的蛋白质共轭物（其中连接了生物相容性材料、脂肪酸和具有生理活性的多肽）具有更长的生理活性多肽半衰期，因此可广泛应用于蛋白质药物领域。
• PROTEIN CONJUGATE COMPRISING NON-PEPTIDYL POLYMER-COUPLED FATTY ACID DERIVATIVE COMPOUND AS LINKER AND PREPARATION METHOD THEREFOR
  申请人：Hanmi Pharm. Co., Ltd.

  公开号：EP3689942A1

  公开（公告）日：2020-08-05

  Provided are a protein conjugate in which a physiologically active polypeptide is linked to a biocompatible material via a non-peptidyl polymer-coupled fatty acid derivative compound serving as a linker, exhibiting an increased duration of physiological activity compared to natural forms and a preparation method therefor. Since an increase in serum half-life of the physiologically active polypeptide of the protein conjugate, in which the biocompatible material, the non-peptidyl polymer-coupled fatty acid derivative compound, and the physiologically active polypeptide are linked, is proved, the protein conjugate may be widely used in the field of protein drugs.

  本发明提供了一种蛋白质共轭物，其中具有生理活性的多肽通过作为连接剂的非肽基聚合物偶联脂肪酸衍生物化合物与生物相容性材料连接，与天然形式的蛋白质共轭物相比，该蛋白质共轭物具有更长的生理活性持续时间及其制备方法。由于生物相容性材料、非肽基聚合物偶联脂肪酸衍生物化合物和生理活性多肽连接在一起的蛋白质共轭物的生理活性多肽的血清半衰期延长，该蛋白质共轭物可广泛应用于蛋白质药物领域。
• Reactive labelling compounds and uses thereof
  申请人：Academia Sinica

  公开号：US10119972B2

  公开（公告）日：2018-11-06

  Provided are azido-BODIPY compounds of formula (I), cyclooctyne-based fluorogenic probes of formula (IV), and activity-based probes of formula (VI). These compounds undergo azide-alkyne cycloadditions (AAC) with to form triazolyl products. The provided compounds are useful for detection and imaging of alkyne-, or azide-containing molecules. Methods for detection and imaging biomolecules using compounds of the present disclosure are disclosed.

  本文提供了式(I)的叠氮-BODIPY化合物、式(IV)的环辛炔基荧光探针和式(VI)的活性探针。这些化合物通过叠氮-炔环加成（AAC）反应生成三唑基产物。所提供的化合物可用于含炔或叠氮分子的检测和成像。本发明公开了使用本公开化合物对生物分子进行检测和成像的方法。