1-((5-bromo-6-chloropyridin-3-yloxy)methyl)-N-methylcyclopropanamine hydrochloride | 959957-79-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-((5-bromo-6-chloropyridin-3-yloxy)methyl)-N-methylcyclopropanamine hydrochloride
• 英文别名: 1-[(5-bromo-6-chloropyridin-3-yl)oxymethyl]-N-methylcyclopropan-1-amine
• CAS: 959957-79-0
• 化学式: C₁₀H₁₂BrClN₂O
• 分子量: 291.575
• InChiKey: KGXLCUFPAQXGLH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  34.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  聚合甲醛 、 1-((5-bromo-6-chloropyridin-3-yloxy)methyl)-N-methylcyclopropanamine hydrochloride 在 甲酸 、 盐酸 作用下， 以 乙醇 为溶剂， 生成 1-[(5-bromo-6-chloropyridin-3-yl)oxymethyl]-N,N-dimethylcyclopropan-1-amine
  参考文献：
  名称：

  Preparation and affinity profile of novel nicotinic ligands

  摘要：

  Novel nicotinic ligands, characterized by the presence of an amino substituted cyclopropane ring connected to a pyridine nucleus, are described. Pharmacological investigation revealed that these compounds exhibit highest affinity for the rat alpha 4 beta 2 subtype of the nicotinic receptor with no affinity for the muscarinic receptor. No appreciable affinity for the muscular or for the ganglionic nicotinic receptor was observed at concentrations up to 10 mu M. The increase in cortical ACh release as well as a positive effect on memory in a social recognition test in rat are exemplified. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.12.075
• 作为产物：
  描述：

  tert-butyl 1-([(5-bromo-6-chloropyridin-3-yl)oxy]methyl)cyclopropyl(methyl)carbamate 在 盐酸 作用下， 以 乙醇 为溶剂， 生成 1-((5-bromo-6-chloropyridin-3-yloxy)methyl)-N-methylcyclopropanamine hydrochloride
  参考文献：
  名称：

  Preparation and affinity profile of novel nicotinic ligands

  摘要：

  Novel nicotinic ligands, characterized by the presence of an amino substituted cyclopropane ring connected to a pyridine nucleus, are described. Pharmacological investigation revealed that these compounds exhibit highest affinity for the rat alpha 4 beta 2 subtype of the nicotinic receptor with no affinity for the muscarinic receptor. No appreciable affinity for the muscular or for the ganglionic nicotinic receptor was observed at concentrations up to 10 mu M. The increase in cortical ACh release as well as a positive effect on memory in a social recognition test in rat are exemplified. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.12.075

文献信息

• Preparation and affinity profile of novel nicotinic ligands
  作者：Yves Charton、Claude Guillonneau、Brian Lockhart、Pierre Lestage、Solo Goldstein

  DOI：10.1016/j.bmcl.2007.12.075

  日期：2008.3

  Novel nicotinic ligands, characterized by the presence of an amino substituted cyclopropane ring connected to a pyridine nucleus, are described. Pharmacological investigation revealed that these compounds exhibit highest affinity for the rat alpha 4 beta 2 subtype of the nicotinic receptor with no affinity for the muscarinic receptor. No appreciable affinity for the muscular or for the ganglionic nicotinic receptor was observed at concentrations up to 10 mu M. The increase in cortical ACh release as well as a positive effect on memory in a social recognition test in rat are exemplified. (C) 2008 Elsevier Ltd. All rights reserved.