tert-butyl N-[2-[3-(6-methoxy-9H-pyrido[2,3-b]indol-4-yl)phenyl]ethyl]carbamate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: tert-butyl N-[2-[3-(6-methoxy-9H-pyrido[2,3-b]indol-4-yl)phenyl]ethyl]carbamate
• 化学式: C₂₅H₂₇N₃O₃
• 分子量: 417.5
• InChiKey: NTSNIJYWWTVIDO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  76.2
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] CaMKII INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS CAMKII ET LEURS UTILISATIONS
  申请人：ALLOSTEROS THERAPEUTICS INC

  公开号：WO2016037106A1

  公开（公告）日：2016-03-10

  The present invention provides compounds useful as inhibitors of Ca2+/calmodulin-dependent protein kinase (CaMKII), compositions thereof, and methods of using the same.

  本发明提供了作为Ca2+/钙调蛋白激酶（CaMKII）抑制剂的化合物，以及这些化合物的组合物和使用方法。
• CaMKII INHIBITORS AND USES THEREOF
  申请人：ALLOSTEROS THERAPEUTICS, INC.

  公开号：US20160024078A1

  公开（公告）日：2016-01-28

  The present invention provides compounds useful as inhibitors of Ca 2+ /calmodulin-dependent protein kinase (CaMKII), compositions thereof, and methods of using the same.

  本发明提供了作为Ca2+/钙调蛋白激酶（CaMKII）抑制剂有用的化合物，其组成物和使用方法。
• CaMKII inhibitors and uses thereof
  申请人：The Johns Hopkins University

  公开号：US10759792B2

  公开（公告）日：2020-09-01

  The present invention provides compounds useful as inhibitors of Ca2+/calmodulin-dependent protein kinase (CaMKII), compositions thereof, and methods of using the same.

  本发明提供了可用作 Ca2+/钙调蛋白依赖性蛋白激酶（CaMKII）抑制剂的化合物、其组合物及其使用方法。
• CAMKII INHIBITORS AND USES THEREOF
  申请人：The Johns Hopkins University

  公开号：EP3189052B1

  公开（公告）日：2021-11-03
• [EN] CaMKII INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE CAMKII ET LEURS UTILISATIONS
  申请人：ALLOSTEROS THERAPEUTICS INC

  公开号：WO2014138212A1

  公开（公告）日：2014-09-12

  The present invention provides compounds useful as inhibitors of Ca2+/calmodulindependent protein kinase (CaMKII), compositions thereof, and methods of using the same. Cardiovascular disease remains the number one cause of death in developed countries. Furthermore, incidence of cardiovascular disease has increased dramatically in developing countries. Although cardiovascular disease usually affects older adults, the antecedents of cardiovascular disease, notably atherosclerosis, begin in early life, making primary prevention efforts necessary from childhood.