舒洛氨酯 | 121-64-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 舒洛氨酯
• 中文别名: N-[4-(氨基磺酰基)苯基]氨基甲酸2-羟乙基酯；磺胺甲酸醇酯
• 英文名称: Sulocarbilate
• 英文别名: 2-hydroxyethyl N-(4-sulfamoylphenyl)carbamate
• CAS: 121-64-2
• 化学式: C₉H₁₂N₂O₅S
• mdl: MFCD00867088
• 分子量: 260.27
• InChiKey: UHXMTGXWCGEIQE-UHFFFAOYSA-N

物化性质

• 密度：
  1.514±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  127
• 氢给体数：
  3
• 氢受体数：
  6

安全信息

• 海关编码：
  2935009090

反应信息

• 作为反应物：
  描述：

  、 双氯非那胺 、 多佐胺-2-6 、 methazolamide 、 (4S)-4-(2-甲基丙基氨基)-7,7-二氧代-5,6-二氢-4H-噻吩并[5,4-b]噻喃-2-磺酰胺 、 舒洛氨酯 生成 乙酰唑胺
  参考文献：
  名称：

  Pharmaceutical preparation comprising an active dispersed on a matrix

  摘要：

  本发明涉及制药技术领域，描述了一种新的优势活性成分制备方法。该新制备方法适用于生产大量药物剂型。在新的制备方法中，活性成分基本上均匀地分散在由脂肪醇、甘油三酯、部分甘油酯和脂肪酸酯等一种或多种赋形剂组成的赋形基质中。

  公开号：

  US07175854B2

文献信息

• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• Esters of hyaluronic acid and their salts.
  申请人：FIDIA S.p.A.

  公开号：EP0216453A2

  公开（公告）日：1987-04-01

  The invention concerns the esters of hyaluronic acid in which all or only a portion of the carboxylic groups of the acid are esterified, and the salts of the partial esters with metals or with pharmacologically acceptable organic bases. The compounds possess interesting and precious bio- plastic and pharmaceutical properties and may be used in innumerable fields, including cosmetics, surgery and medicine. The invention also includes pharmaceutical preparations containing, as an active ingredient, one or more hyaluronic acid esters, or a salt thereof as described above, as well as medicaments containing: 1) a pharmacologically active substance or an association of pharmacologically active substances and 2) a carrying vehicle containing a total or partial ester of hyaluronic acid. The invention includes also various uses of the hyaluronic esters or of the above mentioned medicaments, such as in medicine, surgery or cosmetics. The invention also relates to a new procedure for the preparation of polysaccharide esters containing carboxylic groups, such as in particular the above mentioned hayluronic acid esters.

  本发明涉及全部或仅部分羧基被酯化的透明质酸酯，以及部分酯与金属或药理学上可接受的有机碱的盐。 这些化合物具有有趣而珍贵的生物塑料和药物特性，可用于无数领域，包括化妆品、外科手术和医药。本发明还包括含有一种或多种透明质酸酯或其上述盐类作为活性成分的药物制剂，以及含有以下成分的药品： 1) 一种药理活性物质或药理活性物质的组合，以及 2) 含有全部或部分透明质酸酯的载体。 本发明还包括透明质酸酯或上述药剂的各种用途，如医药、外科手术或化妆品。 本发明还涉及一种制备含有羧基的多糖酯的新工艺，特别是上述海藻糖酸酯。
• Crosslinked carboxy polysaccharides
  申请人：FIDIA S.p.A.

  公开号：EP0341745A1

  公开（公告）日：1989-11-15

  Inter and/or intramolecular cross-linked esters of acid polysaccharides are disclosed in which a part or all of the carboxy groups are esterified with hydroxyl groups of the same molecule and/or of different molecules of the acid polysaccharide. These inner cross-linked esters of polysaccharide acids are useful in the field of biodegradable plastic materials, to manufacture sanitary and surgical articles, in the cosmetic and pharmaceutical fields, in the food industry and in many other industrial fields.

  本发明公开了酸性多糖的分子间和/或分子内交联酯，其中部分或全部羧基与酸性多糖同一分子和/或不同分子的羟基酯化。这些内交联多糖酸酯可用于生物可降解塑料材料领域、卫生和外科用品制造领域、化妆品和医药领域、食品工业和许多其他工业领域。
• New polysaccharide esters
  申请人：FIDIA S.p.A.

  公开号：EP0342557A1

  公开（公告）日：1989-11-23

  New polysaccharide esters are disclosed, and more precisely esters of acidic polysaccharides chosen from the group formed by carboxymethyl­cellulose, carboxymethyl starch and carboxymethyl­chitin. These new esters and some esters of the type already known are useful as medicaments, for the manufacture of pharmaceutical and cosmetic preparations, in the field of biodegradable plastic materials and, therefore, for the manufacture of medical, surgical and sanitary articles, as well as numerous other industrial sectors in the place of acidic polysaccharides now in common use.

  本发明公开了新型多糖酯，更确切地说，是从羧甲基纤维素、羧甲基淀粉和羧甲基几丁质组成的组中选出的酸性多糖酯。这些新的酯类和一些已知的酯类可用作药物，用于制造医药和化妆品制剂，也可用于生物可降解塑料材料领域，因此可用于制造医疗、外科和卫生用品，还可用于许多其他工业部门，取代目前常用的酸性多糖。
• Gellan esters
  申请人：FIDIA S.p.A.

  公开号：EP0518710A1

  公开（公告）日：1992-12-16

  In the total and partial esters of gellan, the esterifying alcohol component is derived from aliphatic, araliphatic, cycloaliphatic or heterocyclic alcohols ; and salts of said partial esters are obtained with inorganic or organic bases. A pharmaceutical preparation contains, as an active ingredient, an effective amount of a gellan ester or one of its salts as defined, or one of its salts together with a pharmaceutically acceptable excipient. The total or partial ester of gellan or a salt thereof is used in ophthalmology, dermatology, otolaryngology, dentistry, angiology, obstetrics or neurology.

  在结冷胶总酯和部分酯中，酯化醇成分来自脂肪族、脂肪族、环脂肪族或杂环醇；所述部分酯的盐可通过无机或有机碱获得。 药物制剂含有有效量的结冷酯或其盐类，或其盐类与药学上可接受的赋形剂一起作为活性成分。 结冷胶总酯或部分酯或其盐可用于眼科、皮肤科、耳鼻喉科、牙科、血管科、产科或神经科。