2-(4-(((2-methoxy-6-phenylpyridin-3yl)methyl)amino)phenoxy)ethanoic acid | 1202162-73-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(4-(((2-methoxy-6-phenylpyridin-3yl)methyl)amino)phenoxy)ethanoic acid
• 英文别名: 2-[4-[(2-Methoxy-6-phenylpyridin-3-yl)methylamino]phenoxy]acetic acid
• CAS: 1202162-73-9
• 化学式: C₂₁H₂₀N₂O₄
• 分子量: 364.401
• InChiKey: DNHJJEKQLXQGKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  80.7
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  methyl 2-carbamoyl-5-dimethylamino-5-phenylpentane-2,4-dienoate 在 lithium aluminium tetrahydride 、 溶剂黄146 、 pyridinium chlorochromate 、 三氟乙酸 、 silver(l) oxide 作用下， 以 四氢呋喃 、 二氯甲烷 、 甲苯 为溶剂， 反应 1.5h， 生成 2-(4-(((2-methoxy-6-phenylpyridin-3yl)methyl)amino)phenoxy)ethanoic acid
  参考文献：
  名称：

  PPAR AGONIST COMPOUNDS, PREPARATION AND USES

  摘要：

  本发明涉及新型PPAR激动剂化合物以及含有它们的药物组合物。根据本发明的化合物在治疗糖尿病和/或脂质代谢异常以及预防心血管病变方面具有相当特殊的治疗兴趣。

  公开号：

  US20110195993A1

文献信息

• COMPOSÉS AGONISTES PPAR, PRÉPARATION ET UTILISATIONS POUR LE TRAITEMENT DU DIABÈTE ET/OU DES DYSLIPIDÉMIES
  申请人：Genfit

  公开号：EP2310371B1

  公开（公告）日：2013-05-15
• THERAPEUTIC COMPOUNDS THAT SUPPRESS PROTEIN ARGININE METHYLTRANSFERASE ACTIVITY FOR REDUCING TUMOR CELL PROLIFERATION
  申请人：Epinova Therapeutics Corp.

  公开号：US20160271149A1

  公开（公告）日：2016-09-22

  The described invention provides methods for modulating gene expression of a gene related to proliferation of a population of tumor cells. The method entails administering a therapeutic amount of a therapeutic compound to a cell, a tissue, or a mammal, wherein the therapeutic amount of the therapeutic compound is effective to suppress methyltransferase activity of a protein arginine methyltransferase. Modulation of the protein arginine methyltransferase activity in turn modulates methylation of a target protein that affects gene expression of the gene, and may suppress the proliferation of the population of tumor cells.
• US8461183B2
  申请人：——

  公开号：US8461183B2

  公开（公告）日：2013-06-11
• [EN] THERAPEUTIC COMPOUNDS THAT SUPPRESS PROTEIN ARGININE METHYLTRANSFERASE ACTIVITY FOR REDUCING TUMOR CELL PROLIFERATION<br/>[FR] COMPOSÉS THÉRAPEUTIQUES QUI SUPPRIMENT L'ACTIVITÉ DE LA PROTÉINE ARGININE MÉTHYLTRANSFÉRASE POUR RÉDUIRE LA PROLIFÉRATION DE CELLULES TUMORALES
  申请人：EPINOVA THERAPEUTICS CORP

  公开号：WO2016149299A1

  公开（公告）日：2016-09-22

  The described invention provides methods for modulating gene expression of a gene related to proliferation of a population of tumor cells. The method entails administering a therapeutic amount of a therapeutic compound to a cell, a tissue, or a mammal, wherein the therapeutic amount of the therapeutic compound is effective to suppress methyltransferase activity of a protein arginine methyltransferase. Modulation of the protein arginine methyltransferase activity in turn modulates methylation of a target protein that affects gene expression of the gene, and may suppress the proliferation of the population of tumor cells.
• PPAR AGONIST COMPOUNDS, PREPARATION AND USES
  申请人：Masson Christophe

  公开号：US20110195993A1

  公开（公告）日：2011-08-11

  The present invention relates to novel PPAR agonist compounds as well as pharmaceutical compositions containing them. The compounds according to the invention are of quite particular therapeutic interest, notably for treating diabetes and/or dyslipidemias, as well as for preventing cardiovascular pathologies.

  本发明涉及新型PPAR激动剂化合物以及含有它们的药物组合物。根据本发明的化合物在治疗糖尿病和/或脂质代谢异常以及预防心血管病变方面具有相当特殊的治疗兴趣。