2-Bis(2-chloroethyl)aminobenzoimidazole | 118517-64-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-Bis(2-chloroethyl)aminobenzoimidazole
• 英文别名: N,N-bis(2-chloroethyl)-1H-benzimidazol-2-amine
• CAS: 118517-64-9
• 化学式: C₁₁H₁₃Cl₂N₃
• 分子量: 258.15
• InChiKey: BFJXMWIEWGBCMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  31.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Bis(2-chloroethyl)aminobenzoimidazole 以 正辛烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 7.0h， 生成 1-(2-Diethylaminoethyl)-2,3-dihydroimidazo<1,2-a>benzoimidazole
  参考文献：
  名称：

  Synthesis and pharmacological activity of n-substituted derivatives of 1-aminoethyl-2,3-dihydroimidazo[1,2-a]benzoimidazole

  摘要：

  DOI：

  10.1007/bf00763272
• 作为产物：
  描述：

  2-Bis(2-hydroxyethyl)aminobenzoimidazole 、 氯化亚砜 生成 2-Bis(2-chloroethyl)aminobenzoimidazole
  参考文献：
  名称：

  ANISIMOVA, V. A.;LEVCHENKO, M. V.;KOVALEV, G. V.;SPASOV, A. A.;DUDCHENKO,+, XIM.-FARMATS. ZH., 22,(1988) N 10, S. 1212-1217

  摘要：

  DOI：

文献信息

• Benzimidazole and indole derivatives as CRF receptor modulators
  申请人：——

  公开号：US20030055037A1

  公开（公告）日：2003-03-20

  Benzimidazole and indole derivatives that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.

  提供作为CRF 1受体选择性调节剂的苯并咪唑和吲哚衍生物。这些化合物在治疗多种中枢神经系统和外周疾病方面具有用途，特别是应激、焦虑、抑郁、心血管疾病和进食障碍。还提供了治疗这些疾病的方法以及包装的药物组合物。发明的化合物还可用作CRF受体定位的探针以及CRF受体结合测定的标准。提供了使用这些化合物进行受体定位研究的方法。
• ANISIMOVA, V. A.;LEVCHENKO, M. V.;KOVALEV, G. V.;SPASOV, A. A.;DUDCHENKO,+, XIM.-FARMATS. ZH., 22,(1988) N 10, S. 1212-1217
  作者：ANISIMOVA, V. A.、LEVCHENKO, M. V.、KOVALEV, G. V.、SPASOV, A. A.、DUDCHENKO,+

  DOI：——

  日期：——
• BENZIMIDAZOLE AND INDOLE DERIVATIVES AS CRF RECEPTOR MODULATORS
  申请人：Neurogen Corporation

  公开号：EP1322620A1

  公开（公告）日：2003-07-02
• [EN] BENZIMIDAZOLE AND INDOLE DERIVATIVES AS CRF RECEPTOR MODULATORS<br/>[FR] DERIVES DE BENZIMIDAZOLE ET D'INDOLE EN TANT QUE MODULATEURS DES RECEPTEURS DE LA CORTICOLIBERINE
  申请人：NEUROGEN CORP

  公开号：WO2002028839A1

  公开（公告）日：2002-04-11

  Benzimidazole and indole derivatives of the formula (I) that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and peripheral disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.
• Synthesis and pharmacological activity of n-substituted derivatives of 1-aminoethyl-2,3-dihydroimidazo[1,2-a]benzoimidazole
  作者：V. A. Anisimova、M. V. Levchenko、G. V. Kovalev、A. A. Spasov、G. P. Dudchenko、A. V. Tsibanev、E. A. Aleksandrova

  DOI：10.1007/bf00763272

  日期：1988.10