(8R,15S,18S,21S,24R,27S)-21-ethyl-18-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-27-(2-hydroxy-2-methylpropyl)-3,8,10,12,14,17,23,26-octamethyl-15-propan-2-yl-24-(2-pyrrolidin-1-ylethylsulfanyl)-1,3,5,7,10,12,14,17,20,23,26-undecazacyclooctacosane-2,4,6,9,11,13,16,19,22,25,28-undecone

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (8R,15S,18S,21S,24R,27S)-21-ethyl-18-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-27-(2-hydroxy-2-methylpropyl)-3,8,10,12,14,17,23,26-octamethyl-15-propan-2-yl-24-(2-pyrrolidin-1-ylethylsulfanyl)-1,3,5,7,10,12,14,17,20,23,26-undecazacyclooctacosane-2,4,6,9,11,13,16,19,22,25,28-undecone
• 化学式: C₄₇H₈₀N₁₂O₁₃S
• 分子量: 1053.3
• InChiKey: LICROEARLRXXQJ-JXBPCENPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  73
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  328
• 氢给体数：
  6
• 氢受体数：
  15

文献信息

• [EN] NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF<br/>[FR] NOUVEAUX DÉRIVÉS DE CYCLOSPORINE ET LEURS UTILISATIONS
  申请人：SU ZHUANG

  公开号：WO2014145686A2

  公开（公告）日：2014-09-18

  The present invention relates to a compound of the Formula (I)): or pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same, a method for treating or preventing viral infections, inflammation, dry eye, central nervous disorders, cardiovascular diseases, cancer, obesity, diabetes, muscular dystrophy, and hair loss.