5-羟基-2-(碘甲基)-4H-吡喃-4-酮 | 16065-34-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 中文名称: 5-羟基-2-(碘甲基)-4H-吡喃-4-酮
• 英文名称: iodokojic acid
• 英文别名: 5-hydroxy-2-iodomethyl-pyran-4-one；5-Hydroxy-2-(iodomethyl)-4H-pyran-4-one；5-hydroxy-2-(iodomethyl)pyran-4-one
• CAS: 16065-34-2
• 化学式: C₆H₅IO₃
• 分子量: 252.008
• InChiKey: AZUVDYQFPSARIG-UHFFFAOYSA-N

物化性质

• 沸点：
  358.7±42.0 °C(Predicted)
• 密度：
  2?+-.0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2932999099

反应信息

• 作为产物：
  描述：

  别麦芽酚 生成 5-羟基-2-(碘甲基)-4H-吡喃-4-酮
  参考文献：
  名称：

  UHER, MICHAL;HUDECOVA, DANIELA;BRTKO, JULIUS;DOBIAS, JOZEF;KOVAC, JAROSLA+

  摘要：

  DOI：

文献信息

• Hydroxy pyranone derivative and preparation method thereof
  申请人：——

  公开号：US20030236299A1

  公开（公告）日：2003-12-25

  The present invention provides hydroxy pyranone derivatives and a method for preparing the hydroxy pyranone derivatives. The hydroxy pyranone derivatives of the present invention are significantly effective in promoting the biosynthesis of collagen and in inhibiting the activity of collagenase, i.e. an enzyme for decomposing collagen, to have anti-wrinkle efficacy, and can be incorporated into medicines or external applications for lessening skin-wrinkles.

  本发明提供了羟基吡喃酮衍生物及其制备方法。本发明的羟基吡喃酮衍生物在促进胶原蛋白的生物合成和抑制胶原酶活性方面具有显著效果，即抑制分解胶原的酶，具有抗皱效果，并可用于制备药物或外用品以减少皮肤皱纹。
• [EN] HYDROXY PYRANONE DERIVATIVE AND PREPARATION METHOD THEREOF<br/>[FR] DERIVE D'HYDROXY PYRANONE ET SON PROCEDE DE PREPARATION
  申请人：AMOREPACIFIC CORP

  公开号：WO2004000836A1

  公开（公告）日：2003-12-31

  The present invention provides hydroxy pyranone derivatives and a method for preparing the hydroxy pyranone derivatives. The hydroxy pyranone derivatives of the present invention are significantly effective in promoting the biosynthesis of collagen and in inhibiting the activity of collagenase, i.e. an enzyme for decomposing collagen, to have anti-wrinkle efficacy, and can be incorporated into medicines or external applications for lessening skin-wrinkles.

  本发明提供了羟基吡喃酮衍生物及其制备方法。本发明的羟基吡喃酮衍生物在促进胶原蛋白的生物合成和抑制胶原酶活性方面具有显著的效果，即抑制分解胶原的酶的活性，具有抗皱效果，并可被用于药物或外用应用以减少皮肤皱纹。
• Kojic acid ether-ester derivatives
  申请人：G.D. Searle & Co.

  公开号：EP0171814A1

  公开（公告）日：1986-02-19

  Kojic acid ether-ester derivatives of formula I take in are useful pharmacological agents for the prevention, management or alleviation of elastase mediated diseases or conditions.

  式 I 所含的曲酸醚酯衍生物是预防、控制或缓解弹性蛋白酶介导的疾病或病症的有效药剂。
• Re-examination of Nucleophilic Substitutionin Chlorokojic Acid
  作者：Michal Uher、Joanna Szymońska、Anna Korenova、Piotr Tomasik

  DOI：10.1007/s007060070106

  日期：2000.3.16

  Chlorokojic acid was reacted with S2O32-, NO3-, N-3(-), I-, and SCN-. Only the three latter nucleophiles substituted the chlorine atom in the 2-CH2Cl group of kojic acid. In none of the products nucleophilic substitution at position 6 of the 4-pyrone could be found. Regular substituion of chlorokojic acid with I- (iodokojic acid), N-3(-) (azidokojic acid), and SCN- (thiocyanato and isothiocyanato kojic acids) was accompanied by formation of allomaltol. Reaction pathways for the formation of allomaltol and 6-substituted allomaltol derivatives are proposed. The latter has been formerly discovered in the reaction of chlorokojic acid with secondary amines.
• HYDROXY PYRANONE DERIVATIVE AND PREPARATION METHOD THEREOF
  申请人：Amorepacific Corporation

  公开号：EP1515966B1

  公开（公告）日：2010-11-03