N-[4-(2-chloro-4-fluorophenyl)-thiazol-2-yl]-2-diethylamino acetamide | 1315460-99-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[4-(2-chloro-4-fluorophenyl)-thiazol-2-yl]-2-diethylamino acetamide
• 英文别名: N-[4-(2-chloro-4-fluorophenyl)-1,3-thiazol-2-yl]-2-(diethylamino)acetamide
• CAS: 1315460-99-1
• 化学式: C₁₅H₁₇ClFN₃OS
• 分子量: 341.837
• InChiKey: FVOKTWCJANQACA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  73.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-(2-chloro-4-fluorophenyl)-1,3-thiazol-2-amine 以 1,4-二氧六环 、 溶剂黄146 为溶剂， 反应 7.0h， 生成 N-[4-(2-chloro-4-fluorophenyl)-thiazol-2-yl]-2-diethylamino acetamide
  参考文献：
  名称：

  Synthesis and local anaesthetic activities of 2-aminothiazole/thiadiazole analogues of lidocaine

  摘要：

  Various 2-aminothiazole and 2-aminothiadiazole derivatives viz N-[4-(2-Chloro-4-fluoro-phenyl)-thiazol-2-yl]-2-substituted acetamides (3a, 4a, 5a) and N-[5-(4-substituted aryl)-[1,3,4]thiadiazol-2-yl]-2-acetamides (3b, 3c, 4b, 4c, 5b, 5c) were synthesized from their corresponding properly substituted 2-aminothiazoles and 2-aminothiadiazoles. Structures of all the newly synthesized compounds were established by analytical and spectral data. Synthesized compounds were screened for their local anaesthetic activity using the rat sciatic nerve model.Various 2-aminothiazole and 2-aminothiadiazole derivatives viz N-[4-(2-Chloro-4-fluoro-phenyl)-thiazol-2-yl]-2-substituted acetamides (3a, 4a, 5a) and N-[5-(4-substituted aryl)-[1,3,4]thiadiazol-2-yl]-2-acetamides (3b, 3c, 4b, 4c, 5b, 5c) were synthesized from their corresponding properly substituted 2-aminothiazoles and 2-aminothiadiazoles. Structures of all the newly synthesized compounds were established by analytical and spectral data. Synthesized compounds were screened for their local anaesthetic activity using the rat sciatic nerve model.

  DOI：

  10.1007/s00044-011-9659-4

文献信息

• Synthesis and local anaesthetic activities of 2-aminothiazole/thiadiazole analogues of lidocaine
  作者：Naveen P. Badiger、Ashraf Khan、M. B. Kalashetti、I. M. Khazi

  DOI：10.1007/s00044-011-9659-4

  日期：2012.8

  Various 2-aminothiazole and 2-aminothiadiazole derivatives viz N-[4-(2-Chloro-4-fluoro-phenyl)-thiazol-2-yl]-2-substituted acetamides (3a, 4a, 5a) and N-[5-(4-substituted aryl)-[1,3,4]thiadiazol-2-yl]-2-acetamides (3b, 3c, 4b, 4c, 5b, 5c) were synthesized from their corresponding properly substituted 2-aminothiazoles and 2-aminothiadiazoles. Structures of all the newly synthesized compounds were established by analytical and spectral data. Synthesized compounds were screened for their local anaesthetic activity using the rat sciatic nerve model.Various 2-aminothiazole and 2-aminothiadiazole derivatives viz N-[4-(2-Chloro-4-fluoro-phenyl)-thiazol-2-yl]-2-substituted acetamides (3a, 4a, 5a) and N-[5-(4-substituted aryl)-[1,3,4]thiadiazol-2-yl]-2-acetamides (3b, 3c, 4b, 4c, 5b, 5c) were synthesized from their corresponding properly substituted 2-aminothiazoles and 2-aminothiadiazoles. Structures of all the newly synthesized compounds were established by analytical and spectral data. Synthesized compounds were screened for their local anaesthetic activity using the rat sciatic nerve model.