[[(2R,3S,4R,5S)-5-(2,4-dioxo-1H-pyrimidin-5-yl)-3,4-dihydroxy-5-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核苷和核苷酸类似物
• 英文名称: [[(2R,3S,4R,5S)-5-(2,4-dioxo-1H-pyrimidin-5-yl)-3,4-dihydroxy-5-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• 化学式: C₁₀H₁₇N₂O₁₅P₃
• 分子量: 498.17
• InChiKey: FOGROKSBHHVCFH-IBNKKVAHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.5
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  268
• 氢给体数：
  8
• 氢受体数：
  15

文献信息

• MANUFACTURING METHODS FOR PRODUCTION OF RNA TRANSCRIPTS
  申请人：Moderna Therapeutics, Inc.

  公开号：EP2971033A1

  公开（公告）日：2016-01-20
• [EN] MANUFACTURING METHODS FOR PRODUCTION OF RNA TRANSCRIPTS<br/>[FR] PROCÉDÉS DE FABRICATION POUR LA PRODUCTION DE TRANSCRITS D'ARN
  申请人：MODERNA THERAPEUTICS INC

  公开号：WO2014152027A1

  公开（公告）日：2014-09-25

  Described are methods for production of RNA transcripts using a non-amplified, linearized DNA tempate in an invitro transcription reaction. Enzymatic 5 ' capping and oligo dT purification can also be included in the methods.
• [EN] RNA COMPOSITIONS TARGETING CLAUDIN-18.2<br/>[FR] COMPOSITIONS D'ARN CIBLANT LA CLAUDINE-18.2
  申请人：BIONTECH SE

  公开号：WO2021198157A1

  公开（公告）日：2021-10-07

  The present disclosure provides RNA technologies for targeting Claudin-18.2 polypeptides. In some embodiments, such RNA technologies can be useful for treatment of diseases associated with positive expression of Claudin-18.2. For example, in some embodiments, such RNA technologies can be useful for treatment of Claudin-18.2 positive cancer, including, e.g, but not limited to biliary cancers, ovarian cancers, gastric cancers, gastro-esophageal cancers, pancreatic cancers. In some embodiments, such RNA technologies can be used in combination therapy (e.g, in combination with a chemotherapeutic agent).