4-(dimethylamino)-N-[(3Z,6Z,9Z,28Z,31Z)-heptatriaconta-3,6,9,28,31-pentaen-19-yl]-N-methylbutanamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-(dimethylamino)-N-[(3Z,6Z,9Z,28Z,31Z)-heptatriaconta-3,6,9,28,31-pentaen-19-yl]-N-methylbutanamide
• 化学式: C₄₄H₈₀N₂O
• 分子量: 653.1
• InChiKey: PDCOXJOFZYALNM-WYJSFBTQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.9
• 重原子数：
  47
• 可旋转键数：
  34
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Amine Cationic Lipids and Uses Thereof
  申请人：Dicerna Pharmaceuticals, Inc.

  公开号：US20140371293A1

  公开（公告）日：2014-12-18

  The present invention relates to lipid compounds and uses thereof. In particular, the compounds include a class of cationic lipids having an amine moiety, such as an amino-amine or an amino-amide moiety. The lipid compounds are useful for in vivo or in vitro delivery of one or more agents (e.g., a polyanionic payload or an antisense payload, such as an RNAi agent).

  本发明涉及脂质化合物及其用途。具体而言，这些化合物包括一类具有胺基团的阳离子脂质，例如氨基-胺或氨基-酰胺基团。这些脂质化合物可用于体内或体外传递一个或多个药物（例如，多聚阴离子荷载物或反义荷载物，如RNAi药物）。
• Process for formulating an anionic agent
  申请人：Dicerna Pharmaceuticals, Inc.

  公开号：US10137201B2

  公开（公告）日：2018-11-27

  Formulations comprising anionic agents such as nucleic acids within a lipid-containing particle methods of formulating a lipid-containing particle comprising an anionic agent such as a nucleic acid, methods for preparing a lipid-containing particle comprising an anionic agent such as a nucleic acid, methods for therapeutic delivery of an anionic agent to a patient in need thereof, where the anionic agent is formulated in a lipid-containing particle as described herein.

  包含阴离子剂（如含脂微粒中的核酸）的制剂 配制包含阴离子剂（如核酸）的含脂微粒的方法、制备包含阴离子剂（如核酸）的含脂微粒的方法、向有需要的患者治疗递送阴离子剂的方法，其中阴离子剂被配制在本文所述的含脂微粒中。
• Amine cationic lipids and uses thereof
  申请人：Dicerna Pharmaceuticals, Inc.

  公开号：US10144725B2

  公开（公告）日：2018-12-04

  The present invention relates to lipid compounds and uses thereof. In particular, the compounds include a class of cationic lipids having an amine moiety, such as an amino-amine or an amino-amide moiety. The lipid compounds are useful for in vivo or in vitro delivery of one or more agents (e.g., a polyanionic payload or an antisense payload, such as an RNAi agent).

  本发明涉及脂质化合物及其用途。特别是，这些化合物包括一类具有胺分子（如氨基胺或氨基酰胺分子）的阳离子脂质。这些脂质化合物可用于体内或体外递送一种或多种制剂（如多阴离子有效载荷或反义有效载荷，如 RNAi 制剂）。
• AMINE CATIONIC LIPIDS AND USES THEREOF
  申请人：Dicerna Pharmaceuticals, Inc.

  公开号：EP2768958B1

  公开（公告）日：2019-08-14
• PROCESS FOR FORMULATING AN ANIONIC AGENT
  申请人：Dicerna Pharmaceuticals, Inc.

  公开号：EP2968149A1

  公开（公告）日：2016-01-20