(6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol;(3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 阿朴菲
• 英文名称: (6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol;(3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine
• 化学式: C36H37FN2O5
• 分子量: 596.7
• InChiKey: HKTDNKMBLOWERQ-VGJUKGHRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.18
• 重原子数：
  44
• 可旋转键数：
  4
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  83.4
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• CRANIAL DELIVERY OF PHARMACEUTICALS
  申请人：Glia LLC

  公开号：EP2968368A2

  公开（公告）日：2016-01-20
• [EN] CRANIAL DELIVERY OF PHARMACEUTICALS<br/>[FR] ADMINISTRATION CRÂNIENNE DE SUBSTANCES PHARMACEUTIQUES
  申请人：GLIA LLC

  公开号：WO2014152385A2

  公开（公告）日：2014-09-25

  A method for rapid delivery of an active compound to innervate a cranial nerve of a subject. Also provided is a method for treating a disease or condition by topically applying a pharmaceutical composition to the face excluding the palpebral part of the eye, in an amount effective for treating the disease or condition.