4-[4-[bis(2-chloroethyl)amino]phenyl]butanoic acid;[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 喜树碱
• 英文名称: 4-[4-[bis(2-chloroethyl)amino]phenyl]butanoic acid;[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate
• 化学式: C47H57Cl2N5O8
• 分子量: 890.9
• InChiKey: PRUADHQOQOIOPS-WAQYZQTGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.47
• 重原子数：
  62
• 可旋转键数：
  14
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.51
• 拓扑面积：
  153
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• Fibroblast Growth Factor Receptor 2-Specific Peptide Reagents and Methods
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN Office of Technology Transfer

  公开号：US20200138979A1

  公开（公告）日：2020-05-07

  The present disclosure relates to Fibroblast Growth Factor Receptor 2-specific peptide reagents, methods for detecting epithelial-derived cancer cells such as esophageal, colorectal, gastric, pancreatic or breast carcinoma cells using the peptide reagents, and methods for targeting such cells using the peptide reagents.
• [EN] FIBROBLAST GROWTH FACTOR RECEPTOR 2-SPECIFIC PEPTIDE REAGENTS AND METHODS<br/>[FR] RÉACTIFS PEPTIDIQUES SPÉCIFIQUES DU RÉCEPTEUR 2 DU FACTEUR DE CROISSANCE DES FIBROBLASTES ET PROCÉDÉS
  申请人：UNIV MICHIGAN REGENTS

  公开号：WO2018237041A1

  公开（公告）日：2018-12-27

  The present disclosure relates to Fibroblast Growth Factor Receptor 2 -specific peptide reagents, methods for detecting epithelial-derived cancer cells such as esophageal, colorectal, gastric, pancreatic or breast carcinoma cells using the peptide reagents, and methods for targeting such cells using the peptide reagents.