heptacosanal | 72934-03-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: heptacosanal
• CAS: 72934-03-3
• 化学式: C₂₇H₅₄O
• 分子量: 394.725
• InChiKey: UEAAOADMOOTTQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13
• 重原子数：
  28
• 可旋转键数：
  25
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  二十七烷醇 在 pyridinium chlorochromate 作用下， 生成 heptacosanal
  参考文献：
  名称：

  摘要：

  Bioassay-guided fractionations of a dichloromethane extract of wheat epicuticular wax allowed the identification of 1-octacosanal and 6-metboxy-2-benzoxazolinone (MBOA) as the major components that stimulate oviposition by the Hessian fly, Mayetiola destructor. These compounds were identified by their mass spectral fragmentation patterns and by comparison of their gas chromatographic retention times with synthetic samples. Synthetic samples of 1-octacosanal or MBOA stimulated significant oviposition when compared with solvent controls. In combination, these compounds elicited a synergistic effect an the number of eggs laid by females compared to when they were presented alone. In a choice bioassay, a mixture of synthetic 1-octacosanal and MBOA in the approximate concentrations determined to be present in one plant equivalent of crude extract stimulated the same amount of oviposition as one plant equivalent of extract. This showed that together these two compounds appear to be responsible for the major proportion of the ovipositional stimulatory activity of the wheat epicuticular wax extract. Comparison of the activity of five straight-chain primary aldehydes with chain lengths from C-22 to C-30 revealed a relationship between chain length and the number of eggs laid by female Hessian flies, with 1-hexacosanal and 1-heptacosanal the most active of the aldehydes tested.

  DOI：

  10.1023/a:1005499907009

文献信息

• Methylene Blue Derivatives
  申请人：Rariy V. Roman

  公开号：US20070116757A1

  公开（公告）日：2007-05-24

  Pharmaceutical compositions comprising a fatty acid salt, a dicarboxylic acid salt, an alkyl sulfate salt, an aryl sulfate salt or an alkyl aryl sulfonate salt of methylene blue or a derivative of methylene blue are described herein. The compositions are preferably administered orally and can be administered as tablets, soft or hard shell capsules (e.g. soft gelatin capsules), suspensions or solutions. The composition can also be formulated as a suppository or enema or rectal administration. The compositions further comprise a pharmaceutically acceptable carrier and optionally one or more pharmaceutically acceptable excipients. Suitable excipients include diluents, binders, plasticizers, lubricants, disintegrants, colorants, stabilizers, surfactants, and combinations thereof. The fatty acid salts, alkyl sulate salts, aryl sulfate salts or alkyl aryl sulfonate salts can be co-mixed or co-melted with one or more fatty acids to make more hydrophobic compositions, which may result in less staining formulations. The compositions can be formulated for immediate release, controlled release such as extended release, delayed release, and pulsatile release, or combinations thereof. In one embodiment, the derivative of methylene blue is methylene dodecylsulfate.

  本文描述了包含脂肪酸盐、二羧酸盐、烷基硫酸盐、芳基硫酸盐或烷基芳基磺酸盐的甲蓝或甲蓝衍生物的制药组合物。这些组合物最好是口服给药，可以制成片剂、软壳或硬壳胶囊（例如软明胶胶囊）、悬浮液或溶液进行给药。该组合物也可以制成栓剂或灌肠剂或直肠给药。这些组合物还包括一种药用可接受载体，以及可选地一种或多种药用可接受的辅料。适用的辅料包括稀释剂、粘结剂、增塑剂、润滑剂、崩解剂、色素、稳定剂、表面活性剂以及它们的组合。脂肪酸盐、烷基硫酸盐、芳基硫酸盐或烷基芳基磺酸盐可以与一种或多种脂肪酸共混或共熔，制成更疏水的组合物，这可能导致更少的染色配方。这些组合物可以制成即时释放、控制释放（如延长释放）、延迟释放和脉冲释放，或者以上述的组合形式。在一个实施例中，甲蓝的衍生物是十二烷基硫酸甲蓝。
• POLYBUTYLENE TEREPHTHALATE RESIN COMPOSITION AND PELLET THEREOF
  申请人：Doi Kumiko

  公开号：US20130309500A1

  公开（公告）日：2013-11-21

  Provided are a polybutylene terephthalate resin composition which is excellent in mold releasability and which can suppress deterioration in molding stability and aggregation of the polybutylene terephthalate resin composition due to blooming of a mold release agent; and a pellet thereof. The polybutylene terephthalate resin composition contains 0.01 to 5.0 parts by mass of (B) a saturated fatty acid ester of a polyglycerol represented by formula (I) described below with respect to 100 parts by mass of (A) a polybutylene terephthalate resin. In formula (I), R 1 s each may be the same or different and are C 19-30 saturated aliphatic acyl groups, and n is an integer from 1 to 10.

  提供了一种聚丁烯对苯二甲酸酯树脂组合物，其具有出模性能优异且可以抑制模具释放剂开花引起的聚丁烯对苯二甲酸酯树脂组合物的成型稳定性恶化和聚集，以及其颗粒。聚丁烯对苯二甲酸酯树脂组合物包含（A）聚丁烯对苯二甲酸酯树脂100质量份中的0.01至5.0质量份的（B）多甘醇的饱和脂肪酸酯，其由以下式（I）表示。在式（I）中，R1s各自可以相同或不同，是C19-30饱和脂肪族酰基，n是1至10的整数。
• N-ACYL AMINO ACID DERIVATIVES FOR TREATING SKIN CONDITIONS SUCH AS CELLULITE
  申请人：Falla Timothy J.

  公开号：US20130096143A1

  公开（公告）日：2013-04-18

  The invention relates to small molecules having biological and therapeutic activity. Particularly, the invention relates to small molecules having lipolytic and anti-adipogenic activity. Two examples of such molecules are 4-methyl-2-(octanoylamino) pentanoic acid and N-isopentyloctanamide. The invention further relates to methods of preventing or treating skin conditions such as cellulite using small molecules having lipolytic and anti-adipogenic activity.

  本发明涉及具有生物和治疗活性的小分子化合物。特别地，本发明涉及具有脂肪分解和抗脂肪生成活性的小分子化合物。其中两个例子是4-甲基-2-(辛酰胺基)戊酸和N-异戊基辛酰胺。本发明还涉及使用具有脂肪分解和抗脂肪生成活性的小分子化合物预防或治疗诸如蜂窝组织炎等皮肤状况的方法。
• Hair-growing agent
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP0688555A2

  公开（公告）日：1995-12-27

  A hair-growing (restoration) agent comprises a carnitine compound represented by the formula (I) : wherein R1 to R3 each represent an alkyl group having 1 to 6 carbon atoms ; R4 represents an aliphatic acyl group having 3 to 31 carbon atoms which may be substituted ; R5 represents an alkyl group having 3 to 31 carbon atoms which may be substituted, or an alkenyl group having 3 to 31 carbon atoms which may be substituted ; and X- represents an anion of a pharmaceutically acceptable acid, as an active ingredient.

  一种生发(修复)剂包括由式(I)代表的肉碱化合物： 其中 R1 至 R3 分别代表具有 1 至 6 个碳原子的烷基；R4 代表具有 3 至 31 个碳原子且可被取代的脂肪酰基；R5 代表具有 3 至 31 个碳原子且可被取代的烷基，或具有 3 至 31 个碳原子且可被取代的烯基；X- 代表作为活性成分的药学上可接受的酸的阴离子。
• Clear aqueous ceramide composition
  申请人：Takasago International Corporation

  公开号：EP1153595A2

  公开（公告）日：2001-11-14

  Provided is a clear aqueous ceramide composition comprising 1.0 to 5.0% by weight, based on the total composition, of a ceramide represented by formula (I): wherein R1 represents a hydrocarbon group having 9 to 17 carbon atoms; and R2 represents an acyl group having 2 to 30 carbon atoms which can contain a hydroxyl group, a long-chain fatty acid having 12 to 24 carbon atoms, a nonionic surface active agent, and water. The clear aqueous composition is useful as cosmetics, bath agents, hair-careproducts, external preparations for the skin, skin protective preparations, particularly medical external preparations for the treatment or protection of the skin, or a component making up these preparations.

  本发明提供了一种透明的含水神经酰胺组合物，该组合物含有按重量计为 1.0 至 5.0%的由式(I)代表的神经酰胺： 其中 R1 代表具有 9 至 17 个碳原子的烃基；R2 代表具有 2 至 30 个碳原子的酰基，该酰基可含有羟基、 具有 12 至 24 个碳原子的长链脂肪酸、非离子表面活性剂和水。这种透明的水性组合物可用作化妆品、沐浴剂、护发产品、皮肤外用制剂、皮肤保护制剂，特别是用于治疗或保护皮肤的医用外用制剂，或这些制剂的组成部分。