2-(methylsulfonylmethyl)pyridine N-oxide | 63422-77-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(methylsulfonylmethyl)pyridine N-oxide
• 英文别名: 2-(methylsulfonylmethyl)-pyridine 1-oxide；Pyridine, 2-[(methylsulfonyl)methyl]-, 1-oxide；2-(methylsulfonylmethyl)-1-oxidopyridin-1-ium
• CAS: 63422-77-5
• 化学式: C₇H₉NO₃S
• 分子量: 187.219
• InChiKey: NXYIHNJEDRYUOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  68
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  间氯过氧苯甲酸 、 、 2-(methylsulfonylmethyl)pyridine 在 甲苯 、 异丙醇 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 16.0h， 以gave 0.6 g的产率得到2-(methylsulfonylmethyl)pyridine N-oxide
  参考文献：
  名称：

  Alkylsulfonyl methyl-substituted pyridine N-oxides

  摘要：

  这项发明涉及用烷基磺酰甲基取代的邻位和/或对位吡啶N-氧化物，在摄影中增加照相速度方面具有实用性。

  公开号：

  US04006150A1

文献信息

• Haloalkyl containing compounds as cysteine protease inhibitors
  申请人：Link O. John

  公开号：US20050182096A1

  公开（公告）日：2005-08-18

  The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.

  本发明涉及抑制半胱氨酸蛋白酶的化合物，特别是cathepsins B、K、L、F和S，因此可用于治疗由这些蛋白酶介导的疾病。本发明涉及包含这些化合物的药物组合物和制备它们的过程。
• Sulfonyl Containing Compounds as Cysteine Protease Inhibitors
  申请人：Mossman Craig J.

  公开号：US20080287446A1

  公开（公告）日：2008-11-20

  The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.

  本发明涉及抑制半胱氨酸蛋白酶的化合物，特别是猫蛋白酶B、K、L、F和S，因此在治疗由这些蛋白酶介导的疾病方面非常有用。本发明涉及包含这些化合物的制药组合物和制备它们的方法。
• SULFONYL CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS
  申请人：Mossman Craig

  公开号：US20110281879A1

  公开（公告）日：2011-11-17

  The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.

  本发明涉及抑制半胱氨酸蛋白酶的化合物，特别是抑制B、K、L、F和S型蛋白酶，因此在治疗由这些蛋白酶介导的疾病中有用。本发明涉及包含这些化合物的制药组合物和其制备方法。
• HALOALKYL CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS
  申请人：ViroBay, Inc.

  公开号：EP1663958B1

  公开（公告）日：2015-02-25
• ALPHA KETOAMIDE COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS
  申请人：Applera Corporation

  公开号：EP1865940A2

  公开（公告）日：2007-12-19