3a,7a-Dihydro-1H-indole-3-acetic acid | 606492-36-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3a,7a-Dihydro-1H-indole-3-acetic acid
• 英文别名: 2-(3a,7a-dihydro-1H-indol-3-yl)acetic acid
• CAS: 606492-36-8
• 化学式: C₁₀H₁₁NO₂
• 分子量: 177.2
• InChiKey: NESCTYVIHZCSFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• PIPERIDINE DERIVATIVES AS HDAC1/2 INHIBITORS
  申请人：Acetylon Pharmaceuticals, Inc.

  公开号：US20160168093A1

  公开（公告）日：2016-06-16

  Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with HDAC1 and/or HDAC2 activity.

  本文提供了化合物、包含这些化合物的药物组合物，以及使用这些化合物治疗与HDAC1和/或HDAC2活性相关的疾病或障碍的方法。
• Piperidine derivatives as HDAC1/2 inhibitors
  申请人：Regenacy Pharmaceuticals, LLC

  公开号：US10239837B2

  公开（公告）日：2019-03-26

  Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with HDAC1 and/or HDAC2 activity.

  本文提供了化合物、包含此类化合物的药物组合物以及使用此类化合物治疗与 HDAC1 和/或 HDAC2 活性相关的疾病或紊乱的方法。
• DEUTERATED OR PARTIALLY DEUTERATED N,N-DIMETHYLTRYPTAMINE COMPOUNDS
  申请人：Small Pharma Ltd

  公开号：US20220202775A1

  公开（公告）日：2022-06-30

  The present invention relates to compounds of formula (I) as defined herein, which comprise a greater proportion of deuterium to protium than naturally found in hydrogen; and compositions, including pharmaceutical compositions, comprising these compounds and optionally analogous compounds of formula (I), which are not deuterium-enriched. These compounds and compositions are of use in therapy, in particular in the treatment of psychiatric or neurological disorders. Varying the amounts of the different compounds within the compositions of the invention allows tailoring of the compositions' therapeutic effects. A particularly efficient synthetic method which enables compounds of formula (I) and related compounds of formula (I′) is also provided.
• US9790180B2
  申请人：——

  公开号：US9790180B2

  公开（公告）日：2017-10-17