p-Fluor-N-(2-morpholinoethyl)benzamid | 64544-18-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-Fluor-N-(2-morpholinoethyl)benzamid
• 英文别名: 4-fluoro-N-(2-morpholin-4-yl-ethyl)-benzamide；p-fluoro-N-(2-morpholinoethyl)-benzamide；Benzamide, 4-fluoro-N-(2-(4-morpholinyl)ethyl)-；4-fluoro-N-(2-morpholin-4-ylethyl)benzamide
• CAS: 64544-18-9
• 化学式: C₁₃H₁₇FN₂O₂
• mdl: MFCD00439108
• 分子量: 252.289
• InChiKey: NOMMINDFYOPRPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.461
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-(2-氨基乙基)吗啉 、 一氧化碳 、 对溴氟苯 在 potassium carbonate 、 双(2-二苯基磷苯基)醚 作用下， 以 甲苯 为溶剂， 105.0 ℃ 、400.01 kPa 条件下， 反应 12.0h， 以72%的产率得到p-Fluor-N-(2-morpholinoethyl)benzamid
  参考文献：
  名称：

  Palladium Nanoparticles Supported on ZIF-8 As an Efficient Heterogeneous Catalyst for Aminocarbonylation

  摘要：

  Pd nanoparticles supported on ZIF-8 (PdNPs/ZIF-8) are described as an efficient heterogeneous catalyst for the aminocarbonylation of bromoarenes in the presence of phosphines and iodoarenes under phosphine-free conditions. The catalyst can be readily prepared and is air-stable. The palladium loading can be as low as 1 wt %, and the catalyst was recycled four times with negligible change in catalytic performance. A variety of pharmaceutically important amides was readily synthesized. A TON of 2540 was easily achieved in a batch reaction by scaling up to a gram scale. The catalyst reported can also be applied to the synthesis of cyclic and primary amides as well as an alkoxycarbonylation reaction to form an ester.

  DOI：

  10.1021/cs400232b

文献信息

• Methods and compositions for using moclobemide
  申请人：——

  公开号：US20020032197A1

  公开（公告）日：2002-03-14

  The invention relates to methods and compositions for treating, managing, and/or preventing certain pain and pain disorder, posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder and premenstrual syndrome, certain sleep disorders, eating disorders, and symptoms thereof using moclobemide, a moclobemide metabolite, a moclobemide derivative or a moclobemide composition.

  本发明涉及使用吗氯贝胺、吗氯贝胺代谢物、吗氯贝胺衍生物或吗氯贝胺组合物治疗、控制和/或预防某些疼痛和疼痛障碍、创伤后应激障碍（PTSD）、经前期精神障碍和经前期综合征、某些睡眠障碍、进食障碍及其症状的方法和组合物。
• FLUORINE CONTAINING COMPOUNDS AND METHODS OF USE THEREOF
  申请人：Ritter Tobias

  公开号：US20120095217A1

  公开（公告）日：2012-04-19

  Fluorinated compounds and methods of making fluorinated compounds are described herein.
• US4210754A
  申请人：——

  公开号：US4210754A

  公开（公告）日：1980-07-01
• [EN] METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING SUBSTANCE ABUSE USING MOCLOBEMIDE<br/>[FR] PROCEDES ET COMPOSITIONS POUR LE TRAITEMENT ET LA PREVENTION DES TOXICOMANIES A L'AIDE DE MOCLOBEMIDE
  申请人：JANUS PHARMACEUTICALS INC

  公开号：WO2000006139A2

  公开（公告）日：2000-02-10

  Methods and compositions for using moclobemide, a moclobemide metabolite, a moclobemide derivative or a moclobemide composition to assist in treating or preventing physical dependence on, or withdrawal symptoms associated with alcohol and drugs, including opioids, other central nervous system depressants such as sedatives, central nervous system stimulants such as cocaine and amphetamines, and other drugs active upon the central nervous system.
• [EN] METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING CERTAIN PSYCHIATRIC AND MEDICAL DISORDERS USING MOCLOBEMIDE<br/>[FR] PROCEDES ET COMPOSITIONS PERMETTANT DE TRAITER ET DE PREVENIR CERTAINS TROUBLES PSYCHIATRIQUES ET MEDICAUX PAR LE MOCLOBEMIDE
  申请人：JANUS PHARMACEUTICALS INC

  公开号：WO2000006140A2

  公开（公告）日：2000-02-10

  Methods and compositions are disclosed utilizing moclobemide, a moclobemide metabolite, a moclobemide derivative or moclobemide composition to assist in treating or preventing low affect disorders, adolescent depression, partial therapy-refractory depression, partial therapy-refractory atypical depression, eating problems and symptoms thereof. The invention also relates to treating somatised symptoms, learning disabilities and conduct disturbances using moclobemide, a moclobemide metabolite, a moclobemide derivative or a moclobemide composition.