Azobenzol-4,4'-diessigsaeure | 101351-18-2

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物 - 环羧酸
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 偶氮苯
• 英文名称: Azobenzol-4,4'-diessigsaeure
• 英文别名: (4,4'-azo-diphenyl)-di-acetic acid；(4,4'-Azo-diphenyl)-di-essigsaeure；p.p'-Azophenylessigsaeure；Azobenzol-diessigsaeure-(4.4')；4-(4-carboxymethyl-phenylazo)-phenylacetic acid；2-[4-[[4-(carboxymethyl)phenyl]diazenyl]phenyl]acetic acid
• CAS: 101351-18-2
• 化学式: C₁₆H₁₄N₂O₄
• 分子量: 298.298
• InChiKey: ALDHICXDFXCJRM-UHFFFAOYSA-N

物化性质

• 沸点：
  561.2±45.0 °C(Predicted)
• 密度：
  1.28±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  99.3
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  苯乙醛酸钾盐 、 Azobenzol-4,4'-diessigsaeure 在 乙酸酐 作用下， 以79%的产率得到3-[4-[[4-(2,5-Dioxo-4-phenylfuran-3-yl)phenyl]diazenyl]phenyl]-4-phenylfuran-2,5-dione
  参考文献：
  名称：

  Diaryl-substituted maleic anhydrides

  摘要：

  DOI：

  10.1021/jo00304a034
• 作为产物：
  描述：

  对硝基苯乙酸 在 sodium amalgam 作用下， 生成 Azobenzol-4,4'-diessigsaeure
  参考文献：
  名称：

  Wittenberg, Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1884, vol. 16, p. 590

  摘要：

  DOI：

文献信息

• Immunoregulatory compounds and derivatives and methods of treating diseases therewith
  申请人：——

  公开号：US20030191186A1

  公开（公告）日：2003-10-09

  Compounds are disclosed having the structure of Formula I: 1 where R 1 , R 3 , and R 4 are independently hydrogen or C 1 to C 4 alkyl, and R 2 is: 2 where R 5 is selected from the group consisting of hydrogen and C 1 to C 4 alkyl, or 3 where R 6 , R 7 and R 8 are independently hydrogen or C 1 to C 4 alkyl; or the esters or pharmacologically acceptable salts thereof. Such compounds may be utilized for the prophylaxis or treatment of various diseases, particularly inflammatory conditions of the GI tract. Methods of treating inflammatory conditions of the GI tract such as inflammatory bowel disease using compounds having the following formula are also disclosed: 4 where R 9 , R 10 and R 11 are independently selected from the group consisting of hydrogen and C 1 to C 4 alkyl, and R 12 is selected from the group consisting of hydrogen and —C(O)R 13 , where R 13 is a C 1 to C 6 alkyl or an aryl group.

  揭示了具有以下结构的化合物：其中R1、R3和R4独立地为氢或C1到C4烷基，而R2为：其中R5选自由氢和C1到C4烷基组成的群；或其中R6、R7和R8独立地为氢或C1到C4烷基；或其酯或药学上可接受的盐。这些化合物可用于预防或治疗各种疾病，特别是消化道的炎症状况。还揭示了使用具有以下公式的化合物治疗消化道炎症状况的方法：其中R9、R10和R11独立地选自由氢和C1到C4烷基组成的群，而R12选自由氢和—C（O）R13，其中R13是C1到C6烷基或芳基。
• IMMUNOREGULATORY COMPOUNDS AND DERIVATIVES AND METHODS OF TREATING DISEASES THEREWITH
  申请人：Ekwuribe Nkem Nnochiri

  公开号：US20070004800A1

  公开（公告）日：2007-01-04

  Compounds are disclosed having the structure of Formula I: where R 1 , R 3 , and R 4 are independently hydrogen or C 1 to C 4 alkyl, and R 2 is: where R 5 is selected from the group consisting of hydrogen and C 1 to C 4 alkyl, or where R 6 , R 7 and R 8 are independently hydrogen or C 1 to C 4 alkyl; or the esters or pharmacologically acceptable salts thereof. Such compounds may be utilized for the prophylaxis or treatment of various diseases, particularly inflammatory conditions of the GI tract. Methods of treating inflammatory conditions of the GI tract such as inflammatory bowel disease using compounds having the following formula are also disclosed: where R 9 , R 10 and R 11 are independently selected from the group consisting of hydrogen and C 1 to C 4 alkyl, and R 12 is selected from the group consisting of hydrogen and —C(O)R 13 , where R 13 is a C 1 to C 6 alkyl or an aryl group.

  本文披露了具有I式结构的化合物：其中R1、R3和R4独立地为氢或C1-C4烷基，而R2为：其中R5选自由氢和C1-C4烷基组成的群，或者其中R6、R7和R8独立地为氢或C1-C4烷基；或其酯或药学上可接受的盐。这些化合物可用于预防或治疗各种疾病，特别是胃肠道的炎症状况。本文还披露了使用具有以下式的化合物治疗胃肠道炎症状况（如炎症性肠病）的方法：其中R9、R10和R11独立地选自由氢和C1-C4烷基组成的群，而R12选自由氢和—C(O)R13，其中R13是C1-C6烷基或芳基。
• Methods and compositions employing 4-aminophenylacetic acid compounds
  申请人：Ekwuribe N. Nnochiri

  公开号：US20070060552A1

  公开（公告）日：2007-03-15

  The invention provides compositions comprising 4-APAA compounds and methods for treating disorders involving inflammation of the digestive system and/or mucosal tissues, such as inflammatory bowel disease. The methods and compositions of the invention also include combinations of 4-APAA compounds and 5-ASA compounds for treatment of such disorders.

  本发明提供了包含4-APAA化合物的组合物以及治疗涉及消化系统和/或粘膜组织炎症的疾病的方法，例如炎性肠病。本发明的方法和组合物还包括4-APAA化合物和5-ASA化合物的组合用于治疗此类疾病。
• Methods of treating inflammatory conditions of the gastrointestinal tract using 4-APAA and compositions thereof
  申请人：Ekwuribe Nnochiri Nkem

  公开号：US06903082B2

  公开（公告）日：2005-06-07

  Compounds are disclosed having the structure of Formula I: where R 1 , R 3 , and R 4 are independently hydrogen or C 1 to C 4 alkyl, and R 2 is: where R 5 is selected from the group consisting of hydrogen and C 1 to C 4 alkyl, or where R 6 , R 7 and R 8 are independently hydrogen or C 1 to C 4 alkyl; or the esters or pharmacologically acceptable salts thereof. Such compounds may be utilized for the prophylaxis or treatment of various diseases, particularly inflammatory conditions of the GI tract. Methods of treating inflammatory conditions of the GI tract such as inflammatory bowel disease using compounds having the following formula are also disclosed: where R 9 , R 10 and R 11 are independently selected from the group consisting of hydrogen and C 1 to C 4 alkyl, and R 12 is selected from the group consisting of hydrogen and —C(O)R 13 , where R 13 is a C 1 to C 6 alkyl or an aryl group.

  本文披露了具有I式结构的化合物：其中R1、R3和R4独立地为氢或C1到C4烷基，而R2为：其中R5选自由氢和C1到C4烷基组成的群，或者R6、R7和R8独立地为氢或C1到C4烷基；或其酯或药理学上可接受的盐。这些化合物可以用于预防或治疗各种疾病，特别是GI道的炎症状况。本文还披露了使用具有以下式的化合物治疗GI道炎症状况，例如炎性肠病的方法：其中R9、R10和R11独立地选自由氢和C1到C4烷基组成的群，而R12选自由氢和—C（O）R13，其中R13为C1到C6烷基或芳基。
• Nerdel,F. et al., Justus Liebigs Annalen der Chemie, 1960, vol. 632, p. 55 - 65
  作者：Nerdel,F. et al.

  DOI：——

  日期：——