3,5-dichloro-N-fluoropyridinium | 107264-05-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3,5-dichloro-N-fluoropyridinium
• 英文别名: 3,5-Dichloro-1-fluoropyridin-1-ium
• CAS: 107264-05-1
• 化学式: C₅H₃Cl₂FN
• 分子量: 166.99
• InChiKey: DLFBDKSWBZTFCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  3.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  在 4-溴苯甲醚 作用下， 以 乙腈 为溶剂， 生成 3,5-二氯吡啶 、 3,5-dichloro-N-fluoropyridinium
  参考文献：
  名称：

  Bockman, T. M.; Lee, K. Y.; Kochi, J. K., Journal of the Chemical Society. Perkin transactions II, 1992, # 9, p. 1581 - 1594

  摘要：

  DOI：

文献信息

• Optically active compound having delta-valerolactone ring and liquid crystal composition comprising same
  申请人：MITSUBISHI RAYON CO., LTD.

  公开号：EP0313379A2

  公开（公告）日：1989-04-26

  An optically active compound having a 8-valerolactone ring, which is represented by the formula: wherein m is an integer of 1 to 8, Z is a group of the formula: in which each of ℓ and k is 1 or 2 and and k satisfy the requirement of 2 ≦ (ℓ + k) ≦ 3, X stands for a direct bond, Y stands for and A1 and A2 independently for -H, -F or -Gℓ, or R stands for or in which n is an integer of from 1 to 18, and * indicates the asymmetric carbon atom. This optically active compound is valuable as a ferroelectric liquid crystal having a large spontaneous polarization or as an additive to a ferroelectric liquid crystal composition.

  一种具有 8-戊内酯环的光学活性化合物，由式表示： 其中 m 是 1 至 8 的整数，Z 是式中的基团： 其中 ℓ 和 k 各为 1 或 2，且 ℓ 和 k 满足 2 ≦ (ℓ + k) ≦ 3 的要求，X 代表直接键、 Y 代表 A1 和 A2 分别代表 -H、-F 或 -Gℓ、 或 R 代表 或 其中 n 为 1 至 18 的整数，* 表示不对称碳原子。 这种光学活性化合物作为具有较大自发极化的铁电液晶或作为铁电液晶组合物的添加剂非常有价值。
• QUINOLINE DERIVATIVE OR SALT THEREOF AND REMEDY FOR CARDIAC DISEASES CONTAINING THE SAME
  申请人：KOWA CO. LTD.

  公开号：EP0638571A1

  公开（公告）日：1995-02-15

  A quinoline derivative represented by general formula (1), a medicinally acceptable salt thereof, and a remedy for cardiac diseases containing the same, wherein ring A represents a furan, dihydrofuran or dioxolane ring, R¹ represents hydroxy, carboxy, alkoxycarbonyl, etc., R²s may be the same or different from each other and each represents hydrogen, alkyl, etc., R³ and R⁴ may be the same or different from each other and each represents hydrogen, halogen, alkyl, amino, alkoxy, etc., R⁵, R⁶, R⁷ and R⁸ may be the same or different from one another and each represents hydrogen or alkyl, m represents an integer of 0 to 3, and symbol ...... means that there may be a double bond formed by R⁶ and R⁸. The compound (1) has a positively inotropic effect on myocardia and an antiarrhythmic effect and can dilate blood vessels without extremely increasing the heart rate. Therefore, a remedy for cardiac diseases containing the same as the active ingredient is remarkably useful for treating cardiac insufficiency, arrhythmia, and so forth.

  一种由通式(1)代表的喹啉衍生物、其药用盐以及含有该衍生物的治疗心脏病的药物，其中环A代表呋喃、二氢呋喃或二氧戊环，R¹代表羟基、羧基、烷氧羰基等，R²s可以相同或不同，各自代表氢、烷基等、R³ 和 R⁴ 可以相同或互不相同，各自代表氢、卤素、烷基、氨基、烷氧基等，R⁵、R⁶、R⁷ 和 R⁸ 可以相同或互不相同，各自代表氢或烷基，m 代表 0 至 3 的整数，符号 ...... 表示 R⁶ 和 R⁸ 可以形成双键。化合物(1)对心肌具有正性肌力作用和抗心律失常作用，并能扩张血管而不会极度增加心率。因此，以该化合物为有效成分的心脏疾病治疗药物对治疗心功能不全、心律失常等有显著作用。
• NOVEL ACETAMIDE DERIVATIVES AND PROTEASE INHIBITORS
  申请人：NIPPON KAYAKU KABUSHIKI KAISHA

  公开号：EP0936216A1

  公开（公告）日：1999-08-18

  The present invention relates to novel acetamide derivatives having a substituted heterocyclic group and consecutive dicarbonyl structures, for example 1-pyrimidinylacetamide compounds, 1-pyrazinylacetamide compounds, 1-triazinylacetamide compounds etc., and these compounds have inhibitory activity on chymotrypsin type proteases and are useful as inhibitors for said enzymes, particularly as chymase inhibitors. The novel acetamide derivatives of the present invention are shown in formula (I) below: wherein R0 is substituted or unsubstituted phenyl; R1 is aryl, heteroaryl or aliphatic lower alkyl which may be substituted or unsubstituted; R2 is substituted or unsustituted alkyl, arylalkyl, or heteroarylalkyl; R3 is hydrogen; acyl group; sulfonyl group; isocyanate group; thiourea; or hydrogen, a lower alkyl or a substituted lower alkyl; aryl (1-7C) alkyl, heteroaryl (1-7C) alkyl, aryl and heteroaryl; X and Y independently represent a nitrogen atom or a carbon atom; and Z is a polymethylene group wherein a hydrogen atom in the polymethylene may be replaced.

  本发明涉及具有取代杂环基团和连续二羰基结构的新型乙酰胺衍生物，例如1-嘧啶基乙酰胺化合物、1-吡嗪基乙酰胺化合物、1-三嗪基乙酰胺化合物等，这些化合物对糜蛋白酶型蛋白酶具有抑制活性，可用作上述酶的抑制剂，特别是糜蛋白酶抑制剂。本发明的新型乙酰胺衍生物如下式(I)所示： 其中 R0 是取代或未取代的苯基；R1 是芳基、杂芳基或可取代或未取代的脂肪族低级烷基；R2 是取代或未取代的烷基、芳烷基或杂芳基；R3 是氢；酰基；磺酰基；异氰酸酯基；硫脲；或氢、低级烷基或取代的低级烷基；芳基（1-7C）烷基、杂芳基（1-7C）烷基、芳基和杂芳基； X 和 Y 独立地代表一个氮原子或一个碳原子；Z 是一个聚亚甲基，其中聚亚甲基中的一个氢原子可被取代。
• ELECTROLYTIC SOLUTION AND DEVICE FOR GENERATING ELECTRIC ENERGY THEREWITH
  申请人：Daikin Industries, Ltd.

  公开号：EP0948073A1

  公开（公告）日：1999-10-06

  An electrolyte containing at least one of dihalodicarbonyl compounds, in which hydrogen atoms of a methylene group between the two carbonyl groups are substituted with halogen atoms, and an electric energy generator comprising the electrolyte, an active material for positive electrode and an active material for negative electrode. The electrolyte has high polarity, high resistance to oxidation and flame retardance, and thus possesses excellent characteristics as the electrolyte for electric energy generators.

  一种含有至少一种二卤代羰基化合物（其中两个羰基之间的亚甲基的氢原子被卤素原子取代）的电解液，以及一种由该电解液、正极活性材料和负极活性材料组成的电能发生器。该电解液具有高极性、高抗氧化性和阻燃性，因此具有作为电能发生器电解液的优良特性。
• 2-HALO-6-O-SUBSTITUTED KETOLIDE DERIVATIVES
  申请人：Abbott Laboratories

  公开号：EP1027362B1

  公开（公告）日：2005-06-29